Hydrogel Scaffolds to Deliver Cell Therapies for Wound Healing

Overview

Journal Front Bioeng Biotechnol

Date 2021 May 20

PMID 34012956

Citations 44

Authors

Dharshan Sivaraj

Kellen Chen

Arhana Chattopadhyay

Dominic Henn

Wanling Wu

Chikage Noishiki

Noah J Magbual

Smiti Mittal

Alana M Mermin-Bunnell

Clark A Bonham

Artem A Trotsyuk

Janos A Barrera

Jagannath Padmanabhan

Michael Januszyk

Geoffrey C Gurtner

Affiliations

Soon will be listed here.

Abstract

Cutaneous wounds are a growing global health burden as a result of an aging population coupled with increasing incidence of diabetes, obesity, and cancer. Cell-based approaches have been used to treat wounds due to their secretory, immunomodulatory, and regenerative effects, and recent studies have highlighted that delivery of stem cells may provide the most benefits. Delivering these cells to wounds with direct injection has been associated with low viability, transient retention, and overall poor efficacy. The use of bioactive scaffolds provides a promising method to improve cell therapy delivery. Specifically, hydrogels provide a physiologic microenvironment for transplanted cells, including mechanical support and protection from native immune cells, and cell-hydrogel interactions may be tailored based on specific tissue properties. In this review, we describe the current and future directions of various cell therapies and usage of hydrogels to deliver these cells for wound healing applications.

Citing Articles

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