Multicomponent Reactions for the Synthesis of Active Pharmaceutical Ingredients

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2022 Aug 26

PMID 36015157

Authors

Angel Cores

Jose Clerigue

Emmanuel Orocio-Rodriguez

J Carlos Menendez

Affiliations

Soon will be listed here.

Abstract

Multicomponent reactions 9i.e., those that engage three or more starting materials to form a product that contains significant fragments of all of them), have been widely employed in the construction of compound libraries, especially in the context of diversity-oriented synthesis. While relatively less exploited, their use in target-oriented synthesis offers significant advantages in terms of synthetic efficiency. This review provides a critical summary of the use of multicomponent reactions for the preparation of active pharmaceutical principles.

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