Mechanochemical Strecker Reaction: Access to α-Aminonitriles and Tetrahydroisoquinolines Under Ball-Milling Conditions

Overview

Journal Chemistry

Specialty Chemistry

Date 2016 Aug 3

PMID 27481327

Citations 11

Authors

Jose G Hernandez

Mathias Turberg

Ingo Schiffers

Carsten Bolm

Affiliations

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Abstract

A mechanochemical version of the Strecker reaction for the synthesis of α-aminonitriles was developed. The milling of aldehydes, amines, and potassium cyanide in the presence of SiO2 gave the corresponding α-aminonitriles in good to high yields. The high efficiency of the mechanochemical Strecker-type multicomponent reaction allowed the one-pot synthesis of tetrahydroisoquinolines after a subsequent internal N-alkylation reaction.

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