The Multifaceted Roles of Autophagy in Infectious, Obstructive, and Malignant Airway Diseases

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2022 Aug 26

PMID 36009490

Authors

Marianna Carinci

Laura Palumbo

Giulia Pellielo

Esther Densu Agyapong

Giampaolo Morciano

Simone Patergnani

Carlotta Giorgi

Paolo Pinton

Alessandro Rimessi

Affiliations

Soon will be listed here.

Abstract

Autophagy is a highly conserved dynamic process by which cells deliver their contents to lysosomes for degradation, thus ensuring cell homeostasis. In response to environmental stress, the induction of autophagy is crucial for cell survival. The dysregulation of this degradative process has been implicated in a wide range of pathologies, including lung diseases, representing a relevant potential target with significant clinical outcomes. During lung disease progression and infections, autophagy may exert both protective and harmful effects on cells. In this review, we will explore the implications of autophagy and its selective forms in several lung infections, such as SARS-CoV-2, Respiratory Syncytial Virus (RSV) and (Mtb) infections, and different lung diseases such as Cystic Fibrosis (CF), Chronic Obstructive Pulmonary Disease (COPD), and Malignant Mesothelioma (MM).

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