Research Progress of Regulatory Cell Death in Coronary Microembolization

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2025 Jan 2

PMID 39744170

Authors

Chen Chang

Wan-Zhong Huang

Ru-Ping Cai

Li-Rong Mo

Qiang Wu

Qiang Su

Affiliations

Soon will be listed here.

Abstract

Coronary microembolization (CME) is defined as atherosclerotic plaque erosion, spontaneous rupture, or rupture of the plaque while undergoing interventional therapy resulting in the formation of tiny emboli that obstruct the coronary microcirculatory system. For percutaneous coronary intervention, CME is a major complication, with a periprocedural incidence of up to 25%. Recent studies have demonstrated that regulatory cell death (RCD) exerts a profound influence on CME through its modulation of inflammatory responses, oxidative stress, cell death, and angiogenesis. RCD, including apoptosis, autophagy, and pyroptosis, is a unique class of genetically highly regulated death patterns pervasive in instances of coronary microembolization. The aim of this review is to summarize the currently known molecular mechanisms underlying CME. Further investigations of the RCD mechanisms may unravel new avenues for the prevention and treatment of CME.

References

Thielmann M, Dorge H, Martin C, Belosjorow S, Schwanke U, van de Sand A . Myocardial dysfunction with coronary microembolization: signal transduction through a sequence of nitric oxide, tumor necrosis factor-alpha, and sphingosine. Circ Res. 2002; 90(7):807-13. DOI: 10.1161/01.res.0000014451.75415.36. View

Zhu H, Wang X, Sun Y, He W, Liang J, Mo B . MicroRNA-486-5p targeting PTEN Protects Against Coronary Microembolization-Induced Cardiomyocyte Apoptosis in Rats by activating the PI3K/AKT pathway. Eur J Pharmacol. 2019; 855:244-251. DOI: 10.1016/j.ejphar.2019.03.045. View

Xie D, Wang Q, Wu G . Research progress in inducing immunogenic cell death of tumor cells. Front Immunol. 2022; 13:1017400. PMC: 9712455. DOI: 10.3389/fimmu.2022.1017400. View

Xuan L, Fu D, Zhen D, Bai D, Yu L, Gong G . Long non-coding RNA Sox2OT promotes coronary microembolization-induced myocardial injury by mediating pyroptosis. ESC Heart Fail. 2022; 9(3):1689-1702. PMC: 9065873. DOI: 10.1002/ehf2.13814. View

Cao Y, Chen Z, Jia J, Chen A, Gao Y, Qian J . Rosuvastatin Alleviates Coronary Microembolization-Induced Cardiac Injury by Suppressing Nox2-Induced ROS Overproduction and Myocardial Apoptosis. Cardiovasc Toxicol. 2022; 22(4):341-351. DOI: 10.1007/s12012-021-09716-4. View

Mo B, Wu X, Wang X, Xie J, Ye Z, Li L . miR-30e-5p Mitigates Hypoxia-Induced Apoptosis in Human Stem Cell-Derived Cardiomyocytes by Suppressing Bim. Int J Biol Sci. 2019; 15(5):1042-1051. PMC: 6535791. DOI: 10.7150/ijbs.31099. View

Zhang K, Wu Q, Jiang S, Ding L, Liu C, Xu M . Pyroptosis: A New Frontier in Kidney Diseases. Oxid Med Cell Longev. 2021; 2021:6686617. PMC: 8102120. DOI: 10.1155/2021/6686617. View

Schwartz R, Burke A, Farb A, Kaye D, Lesser J, Henry T . Microemboli and microvascular obstruction in acute coronary thrombosis and sudden coronary death: relation to epicardial plaque histopathology. J Am Coll Cardiol. 2009; 54(23):2167-73. DOI: 10.1016/j.jacc.2009.07.042. View

Cookson B, Brennan M . Pro-inflammatory programmed cell death. Trends Microbiol. 2001; 9(3):113-4. DOI: 10.1016/s0966-842x(00)01936-3. View

10.

Wang X, Li Y, Lu J, Deng X, Wu Y . Engineering Nanoplatform for Combined Cancer Therapeutics via Complementary Autophagy Inhibition. Int J Mol Sci. 2022; 23(2). PMC: 8776236. DOI: 10.3390/ijms23020657. View

11.

Chang C, Cai R, Su Y, Wu Q, Su Q . Mesenchymal Stem Cell-Derived Exosomal Noncoding RNAs as Alternative Treatments for Myocardial Ischemia-Reperfusion Injury: Current Status and Future Perspectives. J Cardiovasc Transl Res. 2023; 16(5):1085-1098. PMC: 10246878. DOI: 10.1007/s12265-023-10401-w. View

12.

Fernandez Rico C, Konate K, Josse E, Nargeot J, Barrere-Lemaire S, Boisguerin P . Therapeutic Peptides to Treat Myocardial Ischemia-Reperfusion Injury. Front Cardiovasc Med. 2022; 9:792885. PMC: 8891520. DOI: 10.3389/fcvm.2022.792885. View

13.

Su Q, Li L, Zhou Y, Wang J, Liu Y, Ma G . Induction of myocardial PDCD4 in coronary microembolization-related cardiac dysfunction: evidence from a large-animal study. Cell Physiol Biochem. 2014; 34(2):533-42. DOI: 10.1159/000363020. View

14.

Liu Y, Liu Y, Ye S, Feng H, Ma L . A new ferroptosis-related signature model including messenger RNAs and long non-coding RNAs predicts the prognosis of gastric cancer patients. J Transl Int Med. 2023; 11(2):145-155. PMC: 10680379. DOI: 10.2478/jtim-2023-0089. View

15.

Chen Z, Zhou Y, Chen F, Huang J, Li H, Li T . miR-200a-3p Attenuates Coronary Microembolization-Induced Myocardial Injury in Rats by Inhibiting TXNIP/NLRP3-Mediated Cardiomyocyte Pyroptosis. Front Cardiovasc Med. 2021; 8:693257. PMC: 8374895. DOI: 10.3389/fcvm.2021.693257. View

16.

Wang J, Zhao Y, Chen M, Zhang H, Cui J, Li J . Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis. Environ Pollut. 2022; 317:120717. DOI: 10.1016/j.envpol.2022.120717. View

17.

Li T, Chen Z, Zhou Y, Li H, Xie J, Li L . Resveratrol Pretreatment Inhibits Myocardial Apoptosis in Rats Following Coronary Microembolization via Inducing the PI3K/Akt/GSK-3β Signaling Cascade. Drug Des Devel Ther. 2021; 15:3821-3834. PMC: 8434837. DOI: 10.2147/DDDT.S323555. View

18.

Yang T, Liu H, Yang C, Mo H, Wang X, Song X . Galangin Attenuates Myocardial Ischemic Reperfusion-Induced Ferroptosis by Targeting Nrf2/Gpx4 Signaling Pathway. Drug Des Devel Ther. 2023; 17:2495-2511. PMC: 10460190. DOI: 10.2147/DDDT.S409232. View

19.

Xu Y, Lv X, Cai R, Ren Y, He S, Zhang W . Possible implication of miR-142-3p in coronary microembolization induced myocardial injury via ATXN1L/HDAC3/NOL3 axis. J Mol Med (Berl). 2022; 100(5):763-780. DOI: 10.1007/s00109-022-02198-z. View

20.

Schnappauf O, Chae J, Kastner D, Aksentijevich I . The Pyrin Inflammasome in Health and Disease. Front Immunol. 2019; 10:1745. PMC: 6698799. DOI: 10.3389/fimmu.2019.01745. View