Structures and Anti-Inflammatory Evaluation of Phenylpropanoid Derivatives from the Aerial Parts of

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Sep 23

PMID 36142867

Authors

Baixiang Cai

Xinyin Cai

Tao Xu

Jutao Wang

Yang Yu

Affiliations

Soon will be listed here.

Abstract

Seven undescribed phenylpropanoid constituents, including three new bibenzyl derivatives (-) along with four new benzofuran stilbene derivatives (-), were isolated from the aerial parts of . The structures of these compounds were elucidated using a combination of spectroscopic analyses, including UV, IR, HRESIMS, 1D, and 2D NMR. Further, all the compounds were evaluated on the anti-inflammatory activity for their inhibition of nitric oxide (NO) production by RAW 264.7 macrophages cells, and some of them (- and ) displayed inhibitory activity with IC values in the range of 9.3-32.3 μM. Moreover, compound decreased the expression of iNOS in Western blot analysis, suggesting compound is mediated via the suppression of an LPS-induced NF-κB inflammasome pathway.

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