The Emerging Potentials of LncRNA DRAIC in Human Cancers

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Aug 22

PMID 35992823

Authors

Qinfan Yao

Xiuyuan Zhang

Dajin Chen

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNA (lncRNA) is a subtype of noncoding RNA that has more than 200 nucleotides. Numerous studies have confirmed that lncRNA is relevant during multiple biological processes through the regulation of various genes, thus affecting disease progression. The lncRNA DRAIC, a newly discovered lncRNA, has been found to be abnormally expressed in a variety of diseases, particularly cancer. Indeed, the dysregulation of DRAIC expression is closely related to clinicopathological features. It was also reported that DRAIC is key to biological functions such as cell proliferation, autophagy, migration, and invasion. Furthermore, DRAIC is of great clinical significance in human disease. In this review, we discuss the expression signature, clinical characteristics, biological functions, relevant mechanisms, and potential clinical applications of DRAIC in several human diseases.

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References

Rajasekaran S, Nagarajha Selvan L, Dotts K, Kumar R, Rishi P, Khetan V . Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors. Front Oncol. 2019; 9:221. PMC: 6477087. DOI: 10.3389/fonc.2019.00221. View

Conte A, Kisslinger A, Procaccini C, Paladino S, Oliviero O, De Amicis F . Convergent Effects of Resveratrol and PYK2 on Prostate Cells. Int J Mol Sci. 2016; 17(9). PMC: 5037816. DOI: 10.3390/ijms17091542. View

Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre L, Jemal A . Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6):394-424. DOI: 10.3322/caac.21492. View

Prensner J, Chinnaiyan A . The emergence of lncRNAs in cancer biology. Cancer Discov. 2011; 1(5):391-407. PMC: 3215093. DOI: 10.1158/2159-8290.CD-11-0209. View

Yang S, Guo J, Liu J, Liu Z, Chen E, Chen C . Effect of Induction Chemotherapy in Nasopharyngeal Carcinoma: An Updated Meta-Analysis. Front Oncol. 2021; 10:591205. PMC: 7820771. DOI: 10.3389/fonc.2020.591205. View

Colditz J, Rupf B, Maiwald C, Baniahmad A . Androgens induce a distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells. Mol Cell Biochem. 2016; 421(1-2):139-47. DOI: 10.1007/s11010-016-2794-y. View

Parfenyev S, Singh A, Fedorova O, Daks A, Kulshreshtha R, Barlev N . Interplay between p53 and non-coding RNAs in the regulation of EMT in breast cancer. Cell Death Dis. 2021; 12(1):17. PMC: 7791039. DOI: 10.1038/s41419-020-03327-7. View

Gomes L, Rocha C, Martins D, Fiore A, Sarti Kinker G, Bruni-Cardoso A . ATR mediates cisplatin resistance in 3D-cultured breast cancer cells via translesion DNA synthesis modulation. Cell Death Dis. 2019; 10(6):459. PMC: 6561919. DOI: 10.1038/s41419-019-1689-8. View

Yin J, Lang T, Cun D, Zheng Z, Huang Y, Yin Q . pH-Sensitive Nano-Complexes Overcome Drug Resistance and Inhibit Metastasis of Breast Cancer by Silencing Akt Expression. Theranostics. 2017; 7(17):4204-4216. PMC: 5695007. DOI: 10.7150/thno.21516. View

10.

Saha S, Kiran M, Kuscu C, Chatrath A, Wotton D, Mayo M . Long Noncoding RNA DRAIC Inhibits Prostate Cancer Progression by Interacting with IKK to Inhibit NF-κB Activation. Cancer Res. 2020; 80(5):950-963. PMC: 7056510. DOI: 10.1158/0008-5472.CAN-19-3460. View

11.

Ye D, Li Y, Zhang H, Zhou Z, Tang Y, Wu P . Silencing PRSS1 suppresses the growth and proliferation of gastric carcinoma cells via the ERK pathway. Int J Biol Sci. 2021; 17(4):957-971. PMC: 8040304. DOI: 10.7150/ijbs.52591. View

12.

Kast K, Rhiem K . Familial breast cancer - targeted therapy in secondary and tertiary prevention. Breast Care (Basel). 2015; 10(1):27-31. PMC: 4395821. DOI: 10.1159/000380756. View

13.

Gong W, Liu J, Yin J, Cui J, Xiao D, Zhuo W . Resistin facilitates metastasis of lung adenocarcinoma through the TLR4/Src/EGFR/PI3K/NF-κB pathway. Cancer Sci. 2018; 109(8):2391-2400. PMC: 6113506. DOI: 10.1111/cas.13704. View

14.

Ulitsky I, Bartel D . lincRNAs: genomics, evolution, and mechanisms. Cell. 2013; 154(1):26-46. PMC: 3924787. DOI: 10.1016/j.cell.2013.06.020. View

15.

Hu X, Goswami S, Qiu J, Chen Q, Laverdure S, Sherman B . Profiles of Long Non-Coding RNAs and mRNA Expression in Human Macrophages Regulated by Interleukin-27. Int J Mol Sci. 2019; 20(24). PMC: 6941108. DOI: 10.3390/ijms20246207. View

16.

Hayakawa Y, Fox J, Gonda T, Worthley D, Muthupalani S, Wang T . Mouse models of gastric cancer. Cancers (Basel). 2013; 5(1):92-130. PMC: 3730302. DOI: 10.3390/cancers5010092. View

17.

Huang X, Sun L, Wen S, Deng D, Wan F, He X . RNA sequencing of plasma exosomes revealed novel functional long noncoding RNAs in hepatocellular carcinoma. Cancer Sci. 2020; 111(9):3338-3349. PMC: 7469810. DOI: 10.1111/cas.14516. View

18.

Wan L, Pantel K, Kang Y . Tumor metastasis: moving new biological insights into the clinic. Nat Med. 2013; 19(11):1450-64. DOI: 10.1038/nm.3391. View

19.

Masato M, Miyata Y, Kurata H, Ito H, Mitsunari K, Asai A . Oral administration of E-type prostanoid (EP) 1 receptor antagonist suppresses carcinogenesis and development of prostate cancer via upregulation of apoptosis in an animal model. Sci Rep. 2021; 11(1):20279. PMC: 8514456. DOI: 10.1038/s41598-021-99694-y. View

20.

Wang X, Liang H, Xu W, Ma X . Wallenda-Nmo Axis Regulates Growth via Hippo Signaling. Front Cell Dev Biol. 2021; 9:658288. PMC: 8085559. DOI: 10.3389/fcell.2021.658288. View