Wireless Non-Invasive Monitoring of Cholesterol Using a Smart Contact Lens

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2022 Aug 17

PMID 35975449

Authors

Hayoung Song

Haein Shin

Hunkyu Seo

Wonjung Park

Byung Jun Joo

Jeongho Kim

Jeonghyun Kim

Hong Kyun Kim

Jayoung Kim

Jang-Ung Park

Affiliations

Soon will be listed here.

Abstract

Herein, a wireless and soft smart contact lens that enables real-time quantitative recording of cholesterol in tear fluids for the monitoring of patients with hyperlipidemia using a smartphone is reported. This contact lens incorporates an electrochemical biosensor for the continuous detection of cholesterol concentrations, stretchable antenna, and integrated circuits for wireless communication, which makes a smartphone the only device required to operate this lens remotely without obstructing the wearer's vision. The hyperlipidemia rabbit model is utilized to confirm the correlation between cholesterol levels in tear fluid and blood and to confirm the feasibility of this smart contact lens for diagnostic application of cholesterol-related diseases. Further in vivo tests with human subjects demonstrated its good biocompatibility, wearability, and reliability as a non-invasive healthcare device.

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