Mannose Ameliorates Experimental Colitis by Protecting Intestinal Barrier Integrity

Overview

Journal Nat Commun

Specialty Biology

Date 2022 Aug 16

PMID 35974017

Authors

Lijun Dong

Jingwen Xie

Youyi Wang

Honglian Jiang

Kai Chen

Dantong Li

Jing Wang

Yunzhi Liu

Jia He

Jia Zhou

Liyun Zhang

Xiao Lu

Xiaoming Zou

Xiang-Yang Wang

Qingqing Wang

Zhengliang Chen

Daming Zuo

Affiliations

Soon will be listed here.

Abstract

Metabolite alteration has been associated with the pathogenesis of inflammatory bowel disease (IBD), including colitis. Mannose, a natural bioactive monosaccharide that is involved in metabolism and synthesis of glycoproteins, exhibits anti-inflammatory and anti-oxidative activities. We show here that the circulating level of mannose is increased in patients with IBD and mice with experimental colitis. Mannose treatment attenuates intestinal barrier damage in two mouse colitis models, dextran sodium sulfate (DSS)-induced colitis and spontaneous colitis in IL-10-deficient mice. We demonstrate that mannose treatment enhanced lysosomal integrity and limited the release of cathepsin B, preventing mitochondrial dysfunction and myosin light chain kinase (MLCK)-induced tight junction disruption in the context of intestinal epithelial damage. Mannose exerts a synergistic therapeutic effect with mesalamine on mouse colitis. Cumulatively, the results indicate that mannose supplementation may be an optional approach to the treatment of colitis and other diseases associated with intestinal barrier dysfunction.

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