From Serum Metabolites to the Gut: Revealing Metabolic Clues to Susceptibility to Subtypes of Crohn's Disease and Ulcerative Colitis

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2024 Aug 23

PMID 39175573

Authors

Fan Li

Zhaodi Wang

Tongyu Tang

Qi Zhao

Zhi Wang

Xiaoping Han

Zifeng Xu

Yu Chang

Hongyan Li

Sileng Hu

Chanjiao Yu

Shiyu Chang

Yue Liu

Yuqin Li

Affiliations

Soon will be listed here.

Abstract

Background And Aims: Inflammatory bowel disease (IBD) is a common chronic inflammatory bowel disease characterized by diarrhea and abdominal pain. Recently human metabolites have been found to help explain the underlying biological mechanisms of diseases of the intestinal system, so we aimed to assess the causal relationship between human blood metabolites and susceptibility to IBD subtypes.

Methods: We selected a genome-wide association study (GWAS) of 275 metabolites as the exposure factor, and the GWAS dataset of 10 IBD subtypes as the outcome, followed by univariate and multivariate analyses using a two-sample Mendelian randomization study (MR) to study the causal relationship between exposure and outcome, respectively. A series of sensitivity analyses were also performed to ensure the robustness of the results.

Results: A total of 107 metabolites were found to be causally associated on univariate analysis after correcting for false discovery rate (FDR), and a total of 9 metabolites were found to be significantly causally associated on subsequent multivariate and sensitivity analyses. In addition we found causal associations between 7 metabolite pathways and 6 IBD subtypes.

Conclusion: Our study confirms that blood metabolites and certain metabolic pathways are causally associated with the development of IBD subtypes and their parenteral manifestations. The exploration of the mechanisms of novel blood metabolites on IBD may provide new therapeutic ideas for IBD patients.

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