Intestinal Mucosal Barrier Function in Health and Disease

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2009 Oct 27

PMID 19855405

Citations 1526

Authors

Jerrold R Turner

Affiliations

Soon will be listed here.

Abstract

Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between sometimes hostile external environments and the internal milieu. However, mucosae are also responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products. Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli. Here I discuss these discoveries along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.

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