Drug-Loaded Chitosan Scaffolds for Periodontal Tissue Regeneration

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2022 Aug 12

PMID 35956708

Authors

Gamal Abdel Nasser Atia

Hany K Shalaby

Mehrukh Zehravi

Mohamed Mohamady Ghobashy

Hager Abdel Nasser Attia

Zubair Ahmad

Farhat S Khan

Abhijit Dey

Nobendu Mukerjee

Athanasios Alexiou

Md Habibur Rahman

Joanna Klepacka

Agnieszka Najda

Affiliations

Soon will be listed here.

Abstract

Chitosan is a natural anionic polysaccharide with a changeable architecture and an abundance of functional groups; in addition, it can be converted into various shapes and sizes, making it appropriate for a variety of applications. This article examined and summarized current developments in chitosan-based materials, with a focus on the modification of chitosan, and presented an abundance of information about the fabrication and use of chitosan-derived products in periodontal regeneration. Numerous preparation and modification techniques for enhancing chitosan performance, as well as the uses of chitosan and its metabolites, were reviewed critically and discussed in depth in this study. Chitosan-based products may be formed into different shapes and sizes, considering fibers, nanostructures, gels, membranes, and hydrogels. Various drug-loaded chitosan devices were discussed regarding periodontal regeneration.

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