Macro, Micro, and Nano-Inspired Bioactive Polymeric Biomaterials in Therapeutic, and Regenerative Orofacial Applications

Overview

Journal Drug Des Devel Ther

Specialty Pharmacology

Date 2023 Oct 4

PMID 37789970

Authors

Gamal A Atia

Hany K Shalaby

Ali B Roomi

Mohamed M Ghobashy

Hager A Attia

Sara Z Mohamed

Ahmed Abdeen

Mohamed Abdo

Liana Fericean

Ioan Banatean Dunea

Ahmed M Atwa

Tabinda Hasan

Wessam Mady

Afaf Abdelkader

Susan A Ali

Ola A Habotta

Rehab A Azouz

Farag Malhat

Mustafa Shukry

Tarek Foda

Stefania Dinu

Affiliations

Soon will be listed here.

Abstract

Introducing dental polymers has accelerated biotechnological research, advancing tissue engineering, biomaterials development, and drug delivery. Polymers have been utilized effectively in dentistry to build dentures and orthodontic equipment and are key components in the composition of numerous restorative materials. Furthermore, dental polymers have the potential to be employed for medication administration and tissue regeneration. To analyze the influence of polymer-based investigations on practical medical trials, it is required to evaluate the research undertaken in this sector. The present review aims to gather evidence on polymer applications in dental, oral, and maxillofacial reconstruction.

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References

Sun Y, Chen L, Fan X, Pang J . Ultrasound Responsive Smart Implantable Hydrogels for Targeted Delivery of Drugs: Reviewing Current Practices. Int J Nanomedicine. 2022; 17:5001-5026. PMC: 9586127. DOI: 10.2147/IJN.S374247. View

Liu Z, Ran Y, Xi J, Wang J . Polymeric hybrid aerogels and their biomedical applications. Soft Matter. 2020; 16(40):9160-9175. DOI: 10.1039/d0sm01261k. View

Catauro M, Bollino F, Giovanardi R, Veronesi P . Modification of Ti6Al4V implant surfaces by biocompatible TiO/PCL hybrid layers prepared via sol-gel dip coating: Structural characterization, mechanical and corrosion behavior. Mater Sci Eng C Mater Biol Appl. 2017; 74:501-507. DOI: 10.1016/j.msec.2016.12.046. View

Atia G, Shalaby H, Zehravi M, Ghobashy M, Ahmad Z, Khan F . Locally Applied Repositioned Hormones for Oral Bone and Periodontal Tissue Engineering: A Narrative Review. Polymers (Basel). 2022; 14(14). PMC: 9319147. DOI: 10.3390/polym14142964. View

Joung Y, Bae J, Park K . Controlled release of heparin-binding growth factors using heparin-containing particulate systems for tissue regeneration. Expert Opin Drug Deliv. 2008; 5(11):1173-84. DOI: 10.1517/17425240802431811. View

Gugerell A, Kober J, Laube T, Walter T, Nurnberger S, Gronniger E . Electrospun poly(ester-Urethane)- and poly(ester-Urethane-Urea) fleeces as promising tissue engineering scaffolds for adipose-derived stem cells. PLoS One. 2014; 9(3):e90676. PMC: 3942471. DOI: 10.1371/journal.pone.0090676. View

Liu S, Ma J, Xu L, Lin W, Xue W, Huang M . An electrospun polyurethane scaffold-reinforced zwitterionic hydrogel as a biocompatible device. J Mater Chem B. 2020; 8(12):2443-2453. DOI: 10.1039/c9tb02870f. View

Babaeijandaghi F, Shabani I, Seyedjafari E, Naraghi Z, Vasei M, Haddadi-Asl V . Accelerated epidermal regeneration and improved dermal reconstruction achieved by polyethersulfone nanofibers. Tissue Eng Part A. 2010; 16(11):3527-36. DOI: 10.1089/ten.TEA.2009.0829. View

Latimer J, Maekawa S, Yao Y, Wu D, Chen M, Giannobile W . Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects. Front Bioeng Biotechnol. 2021; 9:704048. PMC: 8378232. DOI: 10.3389/fbioe.2021.704048. View

10.

Xun X, Qiu J, Zhang J, Wang H, Han F, Xu X . Triple-functional injectable liposome-hydrogel composite enhances bacteriostasis and osteo/angio-genesis for advanced maxillary sinus floor augmentation. Colloids Surf B Biointerfaces. 2022; 217:112706. DOI: 10.1016/j.colsurfb.2022.112706. View

11.

Acri T, Shin K, Seol D, Laird N, Song I, Geary S . Tissue Engineering for the Temporomandibular Joint. Adv Healthc Mater. 2018; 8(2):e1801236. PMC: 7075314. DOI: 10.1002/adhm.201801236. View

12.

Naomi R, Bahari H, Ridzuan P, Othman F . Natural-Based Biomaterial for Skin Wound Healing (Gelatin vs. Collagen): Expert Review. Polymers (Basel). 2021; 13(14). PMC: 8309321. DOI: 10.3390/polym13142319. View

13.

Larraneta E, Henry M, Irwin N, Trotter J, Perminova A, Donnelly R . Synthesis and characterization of hyaluronic acid hydrogels crosslinked using a solvent-free process for potential biomedical applications. Carbohydr Polym. 2017; 181:1194-1205. PMC: 5742632. DOI: 10.1016/j.carbpol.2017.12.015. View

14.

Moussa D, Aparicio C . Present and future of tissue engineering scaffolds for dentin-pulp complex regeneration. J Tissue Eng Regen Med. 2018; 13(1):58-75. PMC: 6338516. DOI: 10.1002/term.2769. View

15.

Alsaab H, Alharbi F, Alhibs A, Alanazi N, Alshehri B, Saleh M . PLGA-Based Nanomedicine: History of Advancement and Development in Clinical Applications of Multiple Diseases. Pharmaceutics. 2022; 14(12). PMC: 9786338. DOI: 10.3390/pharmaceutics14122728. View

16.

Agrawal S, Budhwani D, Gurjar P, Telange D, Lambole V . Pullulan based derivatives: synthesis, enhanced physicochemical properties, and applications. Drug Deliv. 2022; 29(1):3328-3339. PMC: 9665098. DOI: 10.1080/10717544.2022.2144544. View

17.

Pacheco M, Barbieri D, da Silva C, de Moraes M . A review on orally disintegrating films (ODFs) made from natural polymers such as pullulan, maltodextrin, starch, and others. Int J Biol Macromol. 2021; 178:504-513. DOI: 10.1016/j.ijbiomac.2021.02.180. View

18.

Mancini L, Romandini M, Fratini A, Americo L, Panda S, Marchetti E . Biomaterials for Periodontal and Peri-Implant Regeneration. Materials (Basel). 2021; 14(12). PMC: 8232756. DOI: 10.3390/ma14123319. View

19.

Gursoy U, Kononen E, Huumonen S, Tervahartiala T, Pussinen P, Suominen A . Salivary type I collagen degradation end-products and related matrix metalloproteinases in periodontitis. J Clin Periodontol. 2012; 40(1):18-25. DOI: 10.1111/jcpe.12020. View

20.

Jayabalan M, Shalumon K, Mitha M, Ganesan K, Epple M . Effect of hydroxyapatite on the biodegradation and biomechanical stability of polyester nanocomposites for orthopaedic applications. Acta Biomater. 2009; 6(3):763-75. DOI: 10.1016/j.actbio.2009.09.015. View