Hydrogen Sulfide Donors Activated by Reactive Oxygen Species

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2016 Oct 25

PMID 27774732

Citations 66

Authors

Yu Zhao

Michael D Pluth

Affiliations

Soon will be listed here.

Abstract

Hydrogen sulfide (H S) exhibits promising protective effects in many (patho)physiological processes, as evidenced by recent reports using synthetic H S donors in different biological models. Herein, we report the design and evaluation of compounds denoted PeroxyTCM, which are the first class of reactive oxygen species (ROS)-triggered H S donors. These donors are engineered to release carbonyl sulfide (COS) upon activation, which is quickly hydrolyzed to H S by the ubiquitous enzyme carbonic anhydrase (CA). The donors are stable in aqueous solution and do not release H S until triggered by ROS, such as hydrogen peroxide (H O ), superoxide (O ), and peroxynitrite (ONOO ). We demonstrate ROS-triggered H S donation in live cells and also demonstrate that PeroxyTCM-1 provides protection against H O -induced oxidative damage, suggesting potential future applications of PeroxyTCM and similar scaffolds in H S-related therapies.

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