The Impact of Inflammation-Induced Tumor Plasticity During Myeloid Transformation

Overview

Journal Cancer Discov

Specialty Oncology

Date 2022 Aug 4

PMID 35924979

Authors

Anna Yeaton

Geraldine Cayanan

Sanam Loghavi

Igor Dolgalev

Emmett M Leddin

Christian E Loo

Hedieh Torabifard

Deedra Nicolet

Jingjing Wang

Kate Corrigan

Varvara Paraskevopoulou

Daniel T Starczynowski

Eric Wang

Omar Abdel-Wahab

Aaron D Viny

Richard M Stone

John C Byrd

Olga A Guryanova

Rahul M Kohli

G Andres Cisneros

Aristotelis Tsirigos

Ann-Kathrin Eisfeld

Iannis Aifantis

Maria Guillamot

Affiliations

Soon will be listed here.

Abstract

Significance: Progression from a preleukemic state to transformation, in the presence of TET2 mutations, is coupled with the emergence of inflammation and a novel population of inflammatory monocytes. Genes characteristic of this inflammatory population are associated with the worst prognosis in patients with AML. These studies connect inflammation to progression to leukemia. See related commentary by Pietras and DeGregori, p. 2234 . This article is highlighted in the In This Issue feature, p. 2221.

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