Rhesus Macaque Versus Rat Divergence in the Corticospinal Projectome

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2022 Aug 2

PMID 35917818

Authors

Eleni Sinopoulou

Ephron S Rosenzweig

James M Conner

Daniel Gibbs

Chase A Weinholtz

Janet L Weber

John H Brock

Yvette S Nout-Lomas

Eric Royz

Yoshio Takashima

Jeremy S Biane

Hiromi Kumamaru

Leif A Havton

Michael S Beattie

Jacqueline C Bresnahan

Mark H Tuszynski

Affiliations

Soon will be listed here.

Abstract

We used viral intersectional tools to map the entire projectome of corticospinal neurons associated with fine distal forelimb control in Fischer 344 rats and rhesus macaques. In rats, we found an extraordinarily diverse set of collateral projections from corticospinal neurons to 23 different brain and spinal regions. Remarkably, the vast weighting of this "motor" projection was to sensory systems in both the brain and spinal cord, confirmed by optogenetic and transsynaptic viral intersectional tools. In contrast, rhesus macaques exhibited far heavier and narrower weighting of corticospinal outputs toward spinal and brainstem motor systems. Thus, corticospinal systems in macaques primarily constitute a final output system for fine motor control, whereas this projection in rats exerts a multi-modal integrative role that accesses far broader CNS regions. Unique structural-functional correlations can be achieved by mapping and quantifying a single neuronal system's total axonal output and its relative weighting across CNS targets.

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