Challenges and Progress in Research, Diagnostics, and Therapeutics in Alzheimer's Disease and Related Dementias

Overview

Journal Alzheimers Dement (N Y)

Date 2022 Aug 1

PMID 35910674

Authors

Nikolay V Dokholyan

Richard C Mohs

Randall J Bateman

Affiliations

Soon will be listed here.

Abstract

The health, well-being, and financial security of Americans are greatly impacted by Alzheimer's disease. The forecast paints an upward trajectory with the number of Americans suffering from Alzheimer's disease and related dementia. To discuss the Alzheimer's crisis, The Senate Committee on Finance, Subcommittee on Health Care, held a hearing titled, "The Alzheimer's Crisis: Examining, Testing, and Treatment Pipelines and Fiscal Implications," on December 16, 2020. Here, we summarize and expand on the discussion of the panel and its review of recent progress, ongoing challenges associated with Alzheimer's disease, and potential initiatives that promise to speed progress in developing treatments and improving care.

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References

Schindler S, Bollinger J, Ovod V, Mawuenyega K, Li Y, Gordon B . High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis. Neurology. 2019; 93(17):e1647-e1659. PMC: 6946467. DOI: 10.1212/WNL.0000000000008081. View

Friedman L, McKeehan N, Hara Y, Cummings J, Matthews D, Zhu J . Value-Generating Exploratory Trials in Neurodegenerative Dementias. Neurology. 2021; 96(20):944-954. PMC: 8205472. DOI: 10.1212/WNL.0000000000011774. View

Palmqvist S, Janelidze S, Quiroz Y, Zetterberg H, Lopera F, Stomrud E . Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders. JAMA. 2020; 324(8):772-781. PMC: 7388060. DOI: 10.1001/jama.2020.12134. View

Teunissen C, Verberk I, Thijssen E, Vermunt L, Hansson O, Zetterberg H . Blood-based biomarkers for Alzheimer's disease: towards clinical implementation. Lancet Neurol. 2021; 21(1):66-77. DOI: 10.1016/S1474-4422(21)00361-6. View

Hardy J, Higgins G . Alzheimer's disease: the amyloid cascade hypothesis. Science. 1992; 256(5054):184-5. DOI: 10.1126/science.1566067. View

Udeh-Momoh C, de Jager-Loots C, Price G, Middleton L . Transition from physical to virtual visit format for a longitudinal brain aging study, in response to the Covid-19 pandemic. Operationalizing adaptive methods and challenges. Alzheimers Dement (N Y). 2020; 6(1):e12055. PMC: 7453144. DOI: 10.1002/trc2.12055. View

McDade E, Wang G, Gordon B, Hassenstab J, Benzinger T, Buckles V . Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology. 2018; 91(14):e1295-e1306. PMC: 6177272. DOI: 10.1212/WNL.0000000000006277. View

Dokholyan N, Mohs R, Bateman R . Challenges and progress in research, diagnostics, and therapeutics in Alzheimer's disease and related dementias. Alzheimers Dement (N Y). 2022; 8(1):e12330. PMC: 9322822. DOI: 10.1002/trc2.12330. View

Bateman R, Benzinger T, Berry S, Clifford D, Duggan C, Fagan A . The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model. Alzheimers Dement. 2016; 13(1):8-19. PMC: 5218895. DOI: 10.1016/j.jalz.2016.07.005. View

10.

Ovod V, Ramsey K, Mawuenyega K, Bollinger J, Hicks T, Schneider T . Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis. Alzheimers Dement. 2017; 13(8):841-849. PMC: 5567785. DOI: 10.1016/j.jalz.2017.06.2266. View

11.

Barthelemy N, Li Y, Joseph-Mathurin N, Gordon B, Hassenstab J, Benzinger T . A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease. Nat Med. 2020; 26(3):398-407. PMC: 7309367. DOI: 10.1038/s41591-020-0781-z. View