Antitumor Potential and Structure Characterization of Polysaccharides From Maxim in the Tibetan Plateau

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 Jul 29

PMID 35903443

Authors

Ruixue Gong

Weiguo Cao

Haijun Huang

Bao Yu

Huan Chen

Wei Tao

Quji LuoRong

Juan Luo

Dan Zhang

Affiliations

Soon will be listed here.

Abstract

This study purified two polysaccharides (LBMPs) from Maxim in several steps. The chemical structure of LBMP-2 was determined by HPGPC, FT-IR, IC, H and C NMR, AFM, SEM, and TEM. The results show that LBMP-2 was mainly composed of GalA, and the Mw of LBMP-2 is 23.799 kDa. In addition, the antioxidant activity, and the antitumor activity and were studied. LBMP-2 has excellent antioxidant and antitumor capacity. The inhibition of tumor cell proliferation may result in the inhibition of aerobic respiration and glycolysis. Tumor growth inhibition may inhibit the expression of AMPK in tumors and enhance spleen function. Compared with conventional chemotherapy drug cyclophosphamide, LBMP-2 is less harmful to the body and safer. Therefore, LBMP-2 provides a potential source of antitumor drugs.

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