Innate Immunity Crosstalk with : Pattern Recognition Receptors and Cellular Responses

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Jul 27

PMID 35886908

Authors

Yi Ying Cheok

Grace Min Yi Tan

Chalystha Yie Qin Lee

Suhailah Abdullah

Chung Yeng Looi

Won Fen Wong

Affiliations

Soon will be listed here.

Abstract

is one of the most successful gastric pathogens that has co-existed with human for centuries. is recognized by the host immune system through human pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), C-type lectin like receptors (CLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs), which activate downstream signaling pathways. Following bacterial recognition, the first responders of the innate immune system, including neutrophils, macrophages, and dendritic cells, eradicate the bacteria through phagocytic and inflammatory reaction. This review provides current understanding of the interaction between the innate arm of host immunity and , by summarizing recognition by PRRs, and the subsequent signaling pathway activation in host innate immune cells.

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