Cardiovascular and Neurological Diseases and Association with Helicobacter Pylori Infection-An Overview
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This article investigates the link between () infection and cardiovascular and neurological disorders. Recent research suggests that may play a role in cardiovascular diseases like atherosclerosis, myocardial infarction, and stroke, as well as neurological diseases including Alzheimer's disease, multiple sclerosis, and Parkinson's disease. Cardiovascular Diseases: induces endothelial dysfunction and chronic inflammation, promoting atherosclerotic plaque formation and other cardiac complications. High infection prevalence in cardiovascular patients implies that systemic inflammation from accelerates disease progression. Eradication therapies combined with anti-inflammatory and lipid-lowering treatments may reduce cardiovascular risk. Neurological Diseases: may contribute to Alzheimer's, multiple sclerosis, and Parkinson's through systemic inflammation, neuroinflammation, and autoimmune responses. Increased infection prevalence in these patients suggests bacterial involvement in disease pathogenesis. The eradication of could reduce neuroinflammation and improve outcomes. Discussions and Future Research: Managing infection in clinical practice could impact public health and treatment approaches. Further research is needed to clarify these relationships. Longitudinal and mechanistic studies are essential to fully understand 's role in these conditions. Conclusions: infection is a potential risk factor for various cardiovascular and neurological conditions. Additional research is critical for developing effective prevention and treatment strategies. Targeted therapies, including eradication combined with anti-inflammatory treatments, could improve clinical outcomes. These findings highlight the need for an integrated clinical approach to include evaluation and treatment.
Wang J, Wang X, Luo H, Xie Y, Cao H, Mao L Cell Commun Signal. 2025; 23(1):79.
PMID: 39934861 PMC: 11816533. DOI: 10.1186/s12964-025-02074-6.