Administration of Progesterone on the Day of Oocyte Retrieval to Reverse Accumulation of Fluid in the Endometrial Cavity During Assisted Reproductive Techniques

Overview

Journal JBRA Assist Reprod

Specialty Reproductive Medicine

Date 2022 Jun 28

PMID 35761741

Authors

Mario Cavagna

Claudia G Petersen

Ana L Mauri

Joao Batista A Oliveira

Ricardo R L Baruffi

Jose G Franco Jr

Affiliations

Soon will be listed here.

Abstract

Objective: To determine whether administration of progesterone on the day of oocyte retrieval may reverse accumulation of fluid in the endometrial cavity.

Methods: A total of 50 patients who underwent assisted reproductive technology (ART) cycles with endometrial cavity fluid (ECF) observed by ultrasound at the time of oocyte retrieval were included. Upon the identification of ECF, vaginal administration of natural progesterone was started. Two days later, the endometrial cavity was re-evaluated, and embryo transfer was performed in the absence of ECF.

Results: ECF was absent two days after administration of vaginal progesterone in 47 of the 50 patients (94%). ECF persisted in 3 of the 50 patients (6%). The clinical pregnancy rate per transfer was 34.0%, and the implantation rate was 21.6%.

Conclusion: Our data suggest that, in the presence of ECF, administration of intravaginal progesterone in ART cycles must be initiated on the day of follicle aspiration to reverse ECF and to avoid the deleterious effects of fluid on the blastocyst-endometrial interaction.

Citing Articles

Systematic review analyzing significance of endometrial cavity fluid during assisted reproductive techniques.

Kathuria P, Ghuman N, Yadav G, Singh P, Solanki V, Gaur N Arch Gynecol Obstet. 2023; 309(2):413-425.

PMID: 37179498 DOI: 10.1007/s00404-023-07072-y.

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