Angiogenesis and Endometriosis

Overview

Journal Obstet Gynecol Int

Publisher Wiley

Specialty Gynecology & Obstetrics

Date 2013 Jun 15

PMID 23766765

Citations 57

Authors

Ana Luiza L Rocha

Fernando M Reis

Robert N Taylor

Affiliations

Soon will be listed here.

Abstract

A comprehensive review was performed to survey the role of angiogenesis in the pathogenesis of endometriosis. This is a multifactorial disease in which the development and maintenance of endometriotic implants depend on their invasive capacity and angiogenic potential. The peritoneal fluid of patients with endometriosis is a complex suspension carrying inflammatory cytokines, growth factors, steroid hormones, proangiogenic factors, macrophages, and endometrial and red blood cells. These cells and their signaling products concur to promote the spreading of new blood vessels at the endometriotic lesions and surroundings, which contributes to the endometriotic implant survival. Experimental studies of several antiangiogenic agents demonstrated the regression of endometriotic lesions by reducing their blood supply. Further studies are necessary before these novel agents can be introduced into clinical practice, in particular the establishment of the safety of anti-angiogenic medications in women who are seeking to become pregnant.

Citing Articles

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