Distinct Neuronal Excitability Alterations of Medial Prefrontal Cortex in Early-life Neglect Model of Rats

Overview

Journal Animal Model Exp Med

Date 2022 Jun 24

PMID 35748035

Authors

Yu Zhang

Xiuping Sun

Changsong Dou

Xianglei Li

Ling Zhang

Chuan Qin

Affiliations

Soon will be listed here.

Abstract

Object: Early-life neglect has irreversible emotional effects on the central nervous system. In this work, we aimed to elucidate distinct functional neural changes in medial prefrontal cortex (mPFC) of model rats.

Methods: Maternal separation with early weaning was used as a rat model of early-life neglect. The excitation of glutamatergic and GABAergic neurons in rat mPFC was recorded and analyzed by whole-cell patch clamp.

Results: Glutamatergic and GABAergic neurons of mPFC were distinguished by typical electrophysiological properties. The excitation of mPFC glutamatergic neurons was significantly increased in male groups, while the excitation of mPFC GABAergic neurons was significant in both female and male groups, but mainly in terms of rest membrane potential and amplitude, respectively.

Conclusions: Glutamatergic and GABAergic neurons in medial prefrontal cortex showed different excitability changes in a rat model of early-life neglect, which can contribute to distinct mechanisms for emotional and cognitive manifestations.

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