Impaired Adult Myelination in the Prefrontal Cortex of Socially Isolated Mice

Overview

Journal Nat Neurosci

Date 2012 Nov 13

PMID 23143512

Citations 360

Authors

Jia Liu

Karen Dietz

Jacqueline M DeLoyht

Xiomara Pedre

Dipti Kelkar

Jasbir Kaur

Vincent Vialou

Mary Kay Lobo

David M Dietz

Eric J Nestler

Jeffrey Dupree

Patrizia Casaccia

Affiliations

Soon will be listed here.

Abstract

Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes of the prefrontal cortex (PFC) and impaired adult myelination. Social re-integration was sufficient to normalize behavioral and transcriptional changes. Short periods of isolation affected chromatin and myelin, but did not induce behavioral changes. Thus, myelinating oligodendrocytes in the adult PFC respond to social interaction with chromatin changes, suggesting that myelination acts as a form of adult plasticity.

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