MXene-Derived Multifunctional Biomaterials: New Opportunities for Wound Healing

Overview

Journal Biomater Res

Specialty Biomedical Engineering

Date 2025 Feb 12

PMID 39935790

Authors

Dong Luo

Hui-Qi Zhang

Xin-Yang Xuanyuan

Dan Deng

Zheng-Mao Lu

Wen-Shang Liu

Meng Li

Affiliations

Soon will be listed here.

Abstract

The process of wound healing is frequently impeded by metabolic imbalances within the wound microenvironment. MXenes exhibit exceptional biocompatibility, biodegradability, photothermal conversion efficiency, conductivity, and adaptable surface functionalization, demonstrating marked potential in the development of multifunctional platforms for wound healing. Moreover, the integration of MXenes with other bioactive nanomaterials has been shown to enhance their therapeutic efficacy, paving the way for innovative approaches to wound healing. In this review, we provide a systematic exposition of the mechanisms through which MXenes facilitate wound healing and offer a comprehensive analysis of the current research landscape on MXene-based multifunctional bioactive composites in this field. By delving into the latest scientific discoveries, we identify the existing challenges and potential future trajectories for the advancement of MXenes. Our comprehensive evaluation aims to provide insightful guidance for the formulation of more effective wound healing strategies.

References

Shao H, Luo S, Descamps-Mandine A, Ge K, Lin Z, Taberna P . Synthesis of MAX Phase Nanofibers and Nanoflakes and the Resulting MXenes. Adv Sci (Weinh). 2022; :e2205509. PMC: 9811477. DOI: 10.1002/advs.202205509. View

Lyu S, Dong Z, Xu X, Bei H, Yuen H, James Cheung C . Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration. Bioact Mater. 2023; 27:303-326. PMC: 10140753. DOI: 10.1016/j.bioactmat.2023.04.003. View

van der Pol A, van Gilst W, Voors A, van der Meer P . Treating oxidative stress in heart failure: past, present and future. Eur J Heart Fail. 2018; 21(4):425-435. PMC: 6607515. DOI: 10.1002/ejhf.1320. View

Wang J, Xuan J, Liu Y, Li Z, Han Y, Wang Z . NIR-dependent photothermal-photodynamic synergistic antibacterial mechanism for titanium carbide nanosheets intercalated and delaminated by tetramethylammonium hydroxide. Biomater Adv. 2023; 152:213492. DOI: 10.1016/j.bioadv.2023.213492. View

Fan T, Yan L, He S, Hong Q, Ai F, He S . Biodistribution, degradability and clearance of 2D materials for their biomedical applications. Chem Soc Rev. 2022; 51(18):7732-7751. DOI: 10.1039/d1cs01070k. View

Leguerinel I, Spegagne I, Couvert O, Coroller L, Mafart P . Quantifying the effects of heating temperature, and combined effects of heating medium pH and recovery medium pH on the heat resistance of Salmonella typhimurium. Int J Food Microbiol. 2007; 116(1):88-95. DOI: 10.1016/j.ijfoodmicro.2006.12.016. View

Urbankowski P, Anasori B, Makaryan T, Er D, Kota S, Walsh P . Synthesis of two-dimensional titanium nitride Ti4N3 (MXene). Nanoscale. 2016; 8(22):11385-91. DOI: 10.1039/c6nr02253g. View

Hao S, Han H, Yang Z, Chen M, Jiang Y, Lu G . Recent Advancements on Photothermal Conversion and Antibacterial Applications over MXenes-Based Materials. Nanomicro Lett. 2022; 14(1):178. PMC: 9402885. DOI: 10.1007/s40820-022-00901-w. View

Witherel C, Sao K, Brisson B, Han B, Volk S, Petrie R . Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages. Biomaterials. 2021; 269:120667. PMC: 7870567. DOI: 10.1016/j.biomaterials.2021.120667. View

10.

Buranasin P, Kominato H, Mizutani K, Mikami R, Saito N, Takeda K . Influence of Reactive Oxygen Species on Wound Healing and Tissue Regeneration in Periodontal and Peri-Implant Tissues in Diabetic Patients. Antioxidants (Basel). 2023; 12(9). PMC: 10525304. DOI: 10.3390/antiox12091787. View

11.

Parajuli D, Murali N, K C D, Karki B, Samatha K, Kim A . Advancements in MXene-Polymer Nanocomposites in Energy Storage and Biomedical Applications. Polymers (Basel). 2022; 14(16). PMC: 9415062. DOI: 10.3390/polym14163433. View

12.

Fan L, Chen S, Yang M, Liu Y, Liu J . Metallic Materials for Bone Repair. Adv Healthc Mater. 2023; 13(3):e2302132. DOI: 10.1002/adhm.202302132. View

13.

Li T, Yao L, Liu Q, Gu J, Luo R, Li J . Fluorine-Free Synthesis of High-Purity Ti C T (T=OH, O) via Alkali Treatment. Angew Chem Int Ed Engl. 2018; 57(21):6115-6119. DOI: 10.1002/anie.201800887. View

14.

Shao M, Bigham A, Yousefiasl S, Yiu C, Girish Y, Ghomi M . Recapitulating Antioxidant and Antibacterial Compounds into a Package for Tissue Regeneration: Dual Function Materials with Synergistic Effect. Small. 2023; 19(19):e2207057. DOI: 10.1002/smll.202207057. View

15.

Cooke J . Inflammation and Its Role in Regeneration and Repair. Circ Res. 2019; 124(8):1166-1168. PMC: 6578588. DOI: 10.1161/CIRCRESAHA.118.314669. View

16.

Li S, Wang X, Yan Z, Wang T, Chen Z, Song H . Microneedle Patches with Antimicrobial and Immunomodulating Properties for Infected Wound Healing. Adv Sci (Weinh). 2023; 10(22):e2300576. PMC: 10401127. DOI: 10.1002/advs.202300576. View

17.

Locati M, Curtale G, Mantovani A . Diversity, Mechanisms, and Significance of Macrophage Plasticity. Annu Rev Pathol. 2019; 15:123-147. PMC: 7176483. DOI: 10.1146/annurev-pathmechdis-012418-012718. View

18.

Ma S, Zhan S, Jia Y, Zhou Q . Superior Antibacterial Activity of Fe3O4-TiO2 Nanosheets under Solar Light. ACS Appl Mater Interfaces. 2015; 7(39):21875-83. DOI: 10.1021/acsami.5b06264. View

19.

Zhang X, Tan B, Wu Y, Zhang M, Liao J . A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering. Polymers (Basel). 2021; 13(13). PMC: 8271463. DOI: 10.3390/polym13132100. View

20.

Yuan R, Yang N, Huang Y, Li W, Zeng Y, Liu Z . Layer-by-Layer Microneedle-Mediated rhEGF Transdermal Delivery for Enhanced Wound Epidermal Regeneration and Angiogenesis. ACS Appl Mater Interfaces. 2023; 15(18):21929-21940. DOI: 10.1021/acsami.3c02254. View