Platelet Distribution Width Associated with Short-term Prognosis and Cost in Paediatrics with Partial-thickness Thermal Burns: A Retrospective Comparative Study

Overview

Journal Int Wound J

Specialties Emergency Medicine
Orthopedics

Date 2022 Jun 16

PMID 35706362

Authors

Hailiang Liu

Dongjie Li

Tianjun Sun

Huping Deng

Ligen Li

Jianhua Cai

Chuanan Shen

Affiliations

Soon will be listed here.

Abstract

Platelets exert important roles in burn wound healing and involving in inflammatory regulation and tissue repair. Platelet distribution width (PDW) is an indicator representing platelet morphology and activation. In this study, we try to evaluate the value of PDW in predicting short-term prognosis and cost of paediatrics with partial-thickness thermal burns. This retrospective study enrolled 73 children with partial-thickness thermal burns. The Ability of PDW to predict wound healing was evaluated by receiver operating characteristic (ROC) curve. All 73 patients were assigned into high and low PDW group according to optimal cut-off value from ROC curve. Associations between PDW and 2-weeks healing rate, time to wound healing, in-hospital cost and length of stay were evaluated. Furthermore, Univariate and multivariate logistic regression analysis were used to furtherly evaluate the significance of PDW in wound healing. We found that all baseline characteristics between groups were comparable (all P > .05). High PDW group had a significant higher 2-weeks wound healing rate than those with a low PDW (66.7% versus 32.6%, P < .01). Moreover, the mean time to wound healing of high PDW was obviously shorter than that of low PDW group (15.4 ± 10.1 vs 20.7 ± 10.9, P = .04). Univariate (OR: 0.24, 95%CI: 0.09-0.65, P < .01) and multivariate (OR: 0.15, 95CI%:0.05-0.52, P < .01) analysis confirmed PDW as an independent marker for wound healing. Patients in high PDW group had a significant lower medical burden than low PDW group, including in-hospital cost (13.7 ± 10.6 vs 21.9 ± 16.7, ×103RMB, P = .02) and length of stay (12.2 ± 8.8 vs 19.0 ± 10.8 days, P < .01). In conclusion, PDW can sever as a potential indictor to predict the short-term prognosis of paediatrics with partial thickness thermal burns.

Citing Articles

Platelet distribution width associated with short-term prognosis and cost in paediatrics with partial-thickness thermal burns: A retrospective comparative study.

Liu H, Li D, Sun T, Deng H, Li L, Cai J Int Wound J. 2022; 19(7):1853-1859.

PMID: 35706362 PMC: 9615298. DOI: 10.1111/iwj.13791.

References

Ji S, Ning X, Zhang B, Shi H, Liu Z, Zhang J . Platelet distribution width, platelet count, and plateletcrit in diabetic retinopathy: A systematic review and meta-analysis of PRISMA guidelines. Medicine (Baltimore). 2019; 98(29):e16510. PMC: 6708780. DOI: 10.1097/MD.0000000000016510. View

Parrish C, Haines R, Stewart D, Szabo M, Caradec J, Ziegfeld S . Assessing child quality of life impairments following pediatric burn injuries: Rasch analysis of the children's dermatology life quality index. Qual Life Res. 2019; 29(4):1083-1091. DOI: 10.1007/s11136-019-02380-w. View

Kumar R, Kimble R, Boots R, Pegg S . Treatment of partial-thickness burns: a prospective, randomized trial using Transcyte. ANZ J Surg. 2004; 74(8):622-6. DOI: 10.1111/j.1445-1433.2004.03106.x. View

Johnson R, Richard R . Partial-thickness burns: identification and management. Adv Skin Wound Care. 2003; 16(4):178-87; quiz 188-9. DOI: 10.1097/00129334-200307000-00010. View

Cheng W, Shen C, Zhao D, Zhang H, Tu J, Yuan Z . The epidemiology and prognosis of patients with massive burns: A multicenter study of 2483 cases. Burns. 2019; 45(3):705-716. DOI: 10.1016/j.burns.2018.08.008. View

Etulain J . Platelets in wound healing and regenerative medicine. Platelets. 2018; 29(6):556-568. DOI: 10.1080/09537104.2018.1430357. View

Miller S . Blood platelets in severely injured burn patients. Burns. 1999; 25(2):187. DOI: 10.1016/s0305-4179(98)00158-2. View

Rittie L . Cellular mechanisms of skin repair in humans and other mammals. J Cell Commun Signal. 2016; 10(2):103-20. PMC: 4882309. DOI: 10.1007/s12079-016-0330-1. View

Vloemans A, Hermans M, van der Wal M, Liebregts J, Middelkoop E . Optimal treatment of partial thickness burns in children: a systematic review. Burns. 2013; 40(2):177-90. DOI: 10.1016/j.burns.2013.09.016. View

10.

Yu T, Zhang X, Smiell J, Zhou H, Tan R, Boing E . Healthcare resource utilization, treatment patterns, and cost of care among patients with thermal burns and inpatient autografting in two large privately insured populations in the United States. Burns. 2019; 46(4):825-835. DOI: 10.1016/j.burns.2019.10.019. View

11.

Kim J, Oh S, Kim S, Ahn S, Jang Y, Yang B . Ultrasonographic findings of re-epithelialized skin after partial-thickness burns. Burns Trauma. 2018; 6:21. PMC: 6091158. DOI: 10.1186/s41038-018-0122-3. View

12.

Mitchell M, Kistamgari S, Chounthirath T, McKenzie L, Smith G . Children Younger Than 18 Years Treated for Nonfatal Burns in US Emergency Departments. Clin Pediatr (Phila). 2019; 59(1):34-44. DOI: 10.1177/0009922819884568. View

13.

Lin J, Wu G, Zheng J, Chen Z, Chen X . Prognostic Values of Platelet Distribution Width and Platelet Distribution Width-to-Platelet Ratio in Severe Burns. Shock. 2021; 57(4):494-500. PMC: 8906250. DOI: 10.1097/SHK.0000000000001890. View

14.

Soma Y, Dvonch V, Grotendorst G . Platelet-derived growth factor AA homodimer is the predominant isoform in human platelets and acute human wound fluid. FASEB J. 1992; 6(11):2996-3001. DOI: 10.1096/fasebj.6.11.1644262. View

15.

Kenworthy P, Phillips M, Grisbrook T, Gibson W, Wood F, Edgar D . Monitoring wound healing in minor burns-A novel approach. Burns. 2017; 44(1):70-76. DOI: 10.1016/j.burns.2017.06.007. View

16.

Karabulut B, Arcagok B . New Diagnostic Possibilities for Early Onset Neonatal Sepsis: Red Cell Distribution Width to Platelet Ratio. Fetal Pediatr Pathol. 2019; 39(4):297-306. DOI: 10.1080/15513815.2019.1661051. View

17.

Hoffmann J . Reticulated platelets: analytical aspects and clinical utility. Clin Chem Lab Med. 2014; 52(8):1107-17. DOI: 10.1515/cclm-2014-0165. View

18.

Heng M . Wound healing in adult skin: aiming for perfect regeneration. Int J Dermatol. 2011; 50(9):1058-66. DOI: 10.1111/j.1365-4632.2011.04940.x. View

19.

Opneja A, Kapoor S, Stavrou E . Contribution of platelets, the coagulation and fibrinolytic systems to cutaneous wound healing. Thromb Res. 2019; 179:56-63. PMC: 6556139. DOI: 10.1016/j.thromres.2019.05.001. View

20.

Archer J, Cooper M . Skin grafting of partial-thickness burns in the diabetic foot. J Am Podiatr Med Assoc. 2000; 90(6):320-2. DOI: 10.7547/87507315-90-6-320. View