Effectiveness of Proanthocyanidin Plus Trimetazidine in the Treatment of Non-Small-Cell Lung Cancer with Radiation Heart Injury

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2022 Jun 13

PMID 35692580

Authors

Hang Yin

Yue Zhao

Yucui Sun

Jia Liu

Yingjun Han

Zhentao Dai

Affiliations

Soon will be listed here.

Abstract

This study was intended to explore the effect of proanthocyanidin (PC) combined with trimetazidine in non-small-cell lung cancer (NSCLC) with radiation-induced heart damage (RIHD). It was a prospective randomized controlled study that 86 NSCLC patients with radiation treatment in Cangzhou People's Hospital from January 2019 and June 2021 were enrolled and randomized to either the control group or the study group via the random table method, 43 cases in each group. The control group received trimetazidine, and the study group additionally received PC. The incidence of RIHD-related clinical manifestation, RIHD-related ECG, and RIHD-related cardiac ultrasound change were all lower in the study group. After radiotherapy, the serum level of superoxide dismutase (SOD) was higher, and malondialdehyde (MDA) was lower in the study group when compared with the control group. After radiotherapy, the serum levels of brain natriuretic peptide (BNP), cardiac troponin (cTnT), creatine kinase (CK), and creatine kinase isoenzymes (CKMB) were all lower in the study group when compared with the control group. The efficacy of PC plus trimetazidine for NSCLC with RIHD is superior to trimetazidine alone, and it significantly mitigates radiation-induced inflammatory response and oxidative stress.

Citing Articles

Retracted: Effectiveness of Proanthocyanidin plus Trimetazidine in the Treatment of Non-Small-Cell Lung Cancer with Radiation Heart Injury.

And Alternative Medicine E Evid Based Complement Alternat Med. 2023; 2023:9763418.

PMID: 38125073 PMC: 10732854. DOI: 10.1155/2023/9763418.

Oligomeric Proanthocyanidins: An Updated Review of Their Natural Sources, Synthesis, and Potentials.

Nie F, Liu L, Cui J, Zhao Y, Zhang D, Zhou D Antioxidants (Basel). 2023; 12(5).

PMID: 37237870 PMC: 10215713. DOI: 10.3390/antiox12051004.

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