Mitigation Effect of Proanthocyanidin on Secondary Heart Injury in Rats Caused by Mechanical Trauma

Overview

Journal Sci Rep

Specialty Science

Date 2017 Mar 16

PMID 28294148

Citations 8

Authors

Shuo Ma

Chong Chen

Tingting Cao

Yue Bi

Jicheng Zhou

Xintao Li

Deqin Yu

Shuzhuang Li

Affiliations

Soon will be listed here.

Abstract

Multiple organ dysfunctional syndrome secondary to mechanical trauma (MT) has attracted considerable research attention. The heart is one of the most important organs of the body, and secondary cardiac insufficiency caused by MT seriously affects the quality of life. This study aims to investigate whether proanthocyanidin can alleviate myocardial injury and improve heart function in the process of MT leading to secondary cardiac insufficiency. Noble-Collip drum wasused to prepare MT model in rats. And myocardial apoptosis index was calculated after TUNEL staining. Ventricular intubation was employed to detect heart function. Changes in myocardial ultrastructure were observed using an electron microscope. ELISA was used to detect the content of TNF-α and reactive oxygen species generated from monocytes and cardiomyocytes. The changes in Ca concentration in cardiomyocyte were observed by confocal microscope. Compared with trauma group, the administration group had a decreased apoptosis index of cardiomyocytes, and increased ±dp/dtmax. Meanwhile, proanthocyanidin can inhibit monocytes' TNF-α production, and reduce plasma TNF-α concentration. Moreover, proanthocyanidin can attenuate the excessive oxidative stress reaction of cardiomyocyte, and inhibit calcium overload in cardiomyocytes. In conclusion, proanthocyanidin can effectively ease myocardial damage and improve cardiac function, through anti-inflammatory and antioxidant effects in secondary cardiac insufficiency caused by MT.

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References

Oghlakian G, Maldjian P, Kaluski E, Saric M . Acute myocardial infarction due to left anterior descending coronary artery dissection after blunt chest trauma. Emerg Radiol. 2009; 17(2):149-51. DOI: 10.1007/s10140-009-0799-5. View

Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T . LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell. 2002; 9(1):163-73. DOI: 10.1016/s1097-2765(01)00438-5. View

Tsuchiya S, Yamabe M, Yamaguchi Y, Kobayashi Y, Konno T, Tada K . Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int J Cancer. 1980; 26(2):171-6. DOI: 10.1002/ijc.2910260208. View

Yamakoshi J, Kataoka S, Koga T, Ariga T . Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis. 1999; 142(1):139-49. DOI: 10.1016/s0021-9150(98)00230-5. View

Hassoun H, Kone B, MERCER D, Moody F, Weisbrodt N, Moore F . Post-injury multiple organ failure: the role of the gut. Shock. 2001; 15(1):1-10. DOI: 10.1097/00024382-200115010-00001. View

Zheng H, Yang J, Hou Y, Sun B, Zhang Q, Mou Y . Oligomer procyanidins (F2) isolated from grape seeds inhibits tumor angiogenesis and cell invasion by targeting HIF-1α in vitro. Int J Oncol. 2014; 46(2):708-20. DOI: 10.3892/ijo.2014.2744. View

Schlag G, Redl H, Hallstrom S . The cell in shock: the origin of multiple organ failure. Resuscitation. 1991; 21(2-3):137-80. DOI: 10.1016/0300-9572(91)90044-y. View

Li S, Jiao X, Tao L, Liu H, Cao Y, Lopez B . Tumor necrosis factor-alpha in mechanic trauma plasma mediates cardiomyocyte apoptosis. Am J Physiol Heart Circ Physiol. 2007; 293(3):H1847-52. DOI: 10.1152/ajpheart.00578.2007. View

Jiang L, Yang W, Zou J, Beech D . TRPM2 channel properties, functions and therapeutic potentials. Expert Opin Ther Targets. 2010; 14(9):973-88. DOI: 10.1517/14728222.2010.510135. View

10.

Bagchi D, Swaroop A, Preuss H, Bagchi M . Free radical scavenging, antioxidant and cancer chemoprevention by grape seed proanthocyanidin: an overview. Mutat Res. 2014; 768:69-73. DOI: 10.1016/j.mrfmmm.2014.04.004. View

11.

Xie D, Dixon R . Proanthocyanidin biosynthesis--still more questions than answers?. Phytochemistry. 2005; 66(18):2127-44. DOI: 10.1016/j.phytochem.2005.01.008. View

12.

Kimes B, Brandt B . Properties of a clonal muscle cell line from rat heart. Exp Cell Res. 1976; 98(2):367-81. DOI: 10.1016/0014-4827(76)90447-x. View

13.

Kim H, Kim J, Song H, Park K, Mun K, Ha E . Grape seed proanthocyanidin extract inhibits interleukin-17-induced interleukin-6 production via MAPK pathway in human pulmonary epithelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2011; 383(6):555-62. DOI: 10.1007/s00210-011-0633-y. View

14.

Maffei Facino R, Carini M, Aldini G, Berti F, Rossoni G, Bombardelli E . Procyanidines from Vitis vinifera seeds protect rabbit heart from ischemia/reperfusion injury: antioxidant intervention and/or iron and copper sequestering ability. Planta Med. 1996; 62(6):495-502. DOI: 10.1055/s-2006-957956. View

15.

Li S, Tao L, Jiao X, Liu H, Cao Y, Lopez B . TNFalpha-initiated oxidative/nitrative stress mediates cardiomyocyte apoptosis in traumatic animals. Apoptosis. 2007; 12(10):1795-802. DOI: 10.1007/s10495-007-0108-2. View

16.

Liu X, Li J, Peng X, Lv B, Wang P, Zhao X . Geraniin Inhibits LPS-Induced THP-1 Macrophages Switching to M1 Phenotype via SOCS1/NF-κB Pathway. Inflammation. 2016; 39(4):1421-33. DOI: 10.1007/s10753-016-0374-7. View

17.

Feng Y, Liu Y, Wang D, Zhang X, Liu W, Fu F . Insulin alleviates posttrauma cardiac dysfunction by inhibiting tumor necrosis factor-α-mediated reactive oxygen species production. Crit Care Med. 2013; 41(6):e74-84. DOI: 10.1097/CCM.0b013e318278b6e7. View

18.

Wei T, Wang L, Chen L, Wang C, Zeng C . Acute myocardial infarction and congestive heart failure following a blunt chest trauma. Heart Vessels. 2003; 17(2):77-9. DOI: 10.1007/s003800200048. View

19.

Bagchi D, Bagchi M, Stohs S, Das D, Ray S, Kuszynski C . Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology. 2000; 148(2-3):187-97. DOI: 10.1016/s0300-483x(00)00210-9. View

20.

White D, Maass D, Sanders B, Horton J . Cardiomyocyte intracellular calcium and cardiac dysfunction after burn trauma. Crit Care Med. 2002; 30(1):14-22. DOI: 10.1097/00003246-200201000-00003. View