Ginkgo Biloba in the Management of the COVID-19 Severity

Overview

Journal Arch Pharm (Weinheim)

Specialty Pharmacy

Date 2022 Jun 7

PMID 35672257

Authors

Hayder M Al-Kuraishy

Ali I Al-Gareeb

Ajeet Kaushik

Malgorzata Kujawska

Gaber El-Saber Batiha

Affiliations

Soon will be listed here.

Abstract

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is linked with inflammatory disorders and the development of oxidative stress in extreme cases. Therefore, anti-inflammatory and antioxidant drugs may alleviate these complications. Ginkgo biloba L. folium extract (EGb) is a herbal medicine containing various active constituents. This review aims to provide a critical discussion on the potential role of EGb in the management of coronavirus disease 2019 (COVID-19). The antiviral effect of EGb is mediated by different mechanisms, including blocking SARS-CoV-2 3-chymotrypsin-like protease that provides trans-variant effectiveness. Moreover, EGb impedes the development of pulmonary inflammatory disorders through the diminution of neutrophil elastase activity, the release of proinflammatory cytokines, platelet aggregation, and thrombosis. Thus, EGb can attenuate the acute lung injury and acute respiratory distress syndrome in COVID-19. In conclusion, EGb offers the potential of being used as adjuvant antiviral and symptomatic therapy. Nanosystems enabling targeted delivery, personalization, and booster of effects provide the opportunity for the use of EGb in modern phytotherapy.

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References

Varahachalam S, Lahooti B, Chamaneh M, Bagchi S, Chhibber T, Morris K . Nanomedicine for the SARS-CoV-2: State-of-the-Art and Future Prospects. Int J Nanomedicine. 2021; 16:539-560. PMC: 7837559. DOI: 10.2147/IJN.S283686. View

Dubey A, Chaudhry S, Singh H, Gupta V, Kaushik A . Perspectives on nano-nutraceuticals to manage pre and post COVID-19 infections. Biotechnol Rep (Amst). 2022; 33:e00712. PMC: 8832856. DOI: 10.1016/j.btre.2022.e00712. View

Chu X, Ci X, He J, Wei M, Yang X, Cao Q . A novel anti-inflammatory role for ginkgolide B in asthma via inhibition of the ERK/MAPK signaling pathway. Molecules. 2011; 16(9):7634-48. PMC: 6264276. DOI: 10.3390/molecules16097634. View

Colunga Biancatelli R, Berrill M, Catravas J, Marik P . Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19). Front Immunol. 2020; 11:1451. PMC: 7318306. DOI: 10.3389/fimmu.2020.01451. View

Borenstein R, Hanson B, Markosyan R, Gallo E, Narasipura S, Bhutta M . Ginkgolic acid inhibits fusion of enveloped viruses. Sci Rep. 2020; 10(1):4746. PMC: 7075884. DOI: 10.1038/s41598-020-61700-0. View

Kaushik D, Bhandari R, Kuhad A . TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2. Expert Opin Ther Targets. 2021; 25(6):491-508. PMC: 8095161. DOI: 10.1080/14728222.2021.1918103. View

Wu Y, Li S, Zu X, Du J, Wang F . Ginkgo biloba extract improves coronary artery circulation in patients with coronary artery disease: contribution of plasma nitric oxide and endothelin-1. Phytother Res. 2008; 22(6):734-9. DOI: 10.1002/ptr.2335. View

Li Y, Zhang Y, Wen M, Zhang J, Zhao X, Zhao Y . Ginkgo biloba extract prevents acute myocardial infarction and suppresses the inflammation‑ and apoptosis‑regulating p38 mitogen‑activated protein kinases, nuclear factor‑κB and B‑cell lymphoma 2 signaling pathways. Mol Med Rep. 2017; 16(3):3657-3663. DOI: 10.3892/mmr.2017.6999. View

Al-Kuraishy H, Al-Gareeb A, Alkazmi L, Alexiou A, El-Saber Batiha G . Levamisole Therapy in COVID-19. Viral Immunol. 2021; 34(10):722-725. DOI: 10.1089/vim.2021.0042. View

10.

Kaushik A . Manipulative magnetic nanomedicine: the future of COVID-19 pandemic/endemic therapy. Expert Opin Drug Deliv. 2020; 18(5):531-534. DOI: 10.1080/17425247.2021.1860938. View

11.

Gaber A, Refat M, Belal A, El-Deen I, Hassan N, Zakaria R . New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study. Molecules. 2021; 26(8). PMC: 8071257. DOI: 10.3390/molecules26082288. View

12.

Breitinger U, Ali N, Sticht H, Breitinger H . Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin Inhibitors. Front Microbiol. 2021; 12:692423. PMC: 8297954. DOI: 10.3389/fmicb.2021.692423. View

13.

Koch E . Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomedicine. 2005; 12(1-2):10-6. DOI: 10.1016/j.phymed.2004.02.002. View

14.

Kujawska M, Ewertowska M, Ignatowicz E, Adamska T, Szaefer H, Gramza-Michalowska A . Evaluation of Safety and Antioxidant Activity of Yellow Tea (Camellia sinensis) Extract for Application in Food. J Med Food. 2016; 19(3):330-6. DOI: 10.1089/jmf.2015.0114. View

15.

Tulsulkar J, Shah Z . Ginkgo biloba prevents transient global ischemia-induced delayed hippocampal neuronal death through antioxidant and anti-inflammatory mechanism. Neurochem Int. 2012; 62(2):189-97. PMC: 3568207. DOI: 10.1016/j.neuint.2012.11.017. View

16.

Boozari M, Hosseinzadeh H . Natural products for COVID-19 prevention and treatment regarding to previous coronavirus infections and novel studies. Phytother Res. 2020; 35(2):864-876. DOI: 10.1002/ptr.6873. View

17.

Ryu K, Han H, Lee S, Jeon S, Im G, Lee B . Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding time. Thromb Res. 2009; 124(3):328-34. DOI: 10.1016/j.thromres.2009.02.010. View

18.

Fuentes J, de Camargo A, Atala E, Gotteland M, Olea-Azar C, Speisky H . Quercetin Oxidation Metabolite Present in Onion Peel Protects Caco-2 Cells against the Oxidative Stress, NF-kB Activation, and Loss of Epithelial Barrier Function Induced by NSAIDs. J Agric Food Chem. 2021; 69(7):2157-2167. DOI: 10.1021/acs.jafc.0c07085. View

19.

Andersson U . The cholinergic anti-inflammatory pathway alleviates acute lung injury. Mol Med. 2020; 26(1):64. PMC: 7322708. DOI: 10.1186/s10020-020-00184-0. View

20.

Campos D, Navarro S, Llamas-Gonzalez Y, Sugasti M, Gonzalez-Santamaria J . Broad Antiviral Activity of Ginkgolic Acid against Chikungunya, Mayaro, Una, and Zika Viruses. Viruses. 2020; 12(4). PMC: 7232212. DOI: 10.3390/v12040449. View