Imaging Perivascular Space Structure and Function Using Brain MRI

Overview

Journal Neuroimage

Specialty Radiology

Date 2022 May 24

PMID 35609770

Authors

Giuseppe Barisano

Kirsten M Lynch

Francesca Sibilia

Haoyu Lan

Nien-Chu Shih

Farshid Sepehrband

Jeiran Choupan

Affiliations

Soon will be listed here.

Abstract

In this article, we provide an overview of current neuroimaging methods for studying perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing number of studies highlighted the role of PVS in cerebrospinal/interstial fluid circulation and clearance of cerebral waste products and their association with neurological diseases. Novel strategies and techniques have been introduced to improve the quantification of PVS and to investigate their function and morphological features in physiological and pathological conditions. After a brief introduction on the anatomy and physiology of PVS, we examine the latest technological developments to quantitatively analyze the structure and function of PVS in humans with MRI. We describe the applications, advantages, and limitations of these methods, providing guidance and suggestions on the acquisition protocols and analysis techniques that can be applied to study PVS in vivo. Finally, we review the human neuroimaging studies on PVS across the normative lifespan and in the context of neurological disorders.

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