Volumetric Distribution of Perivascular Space in Relation to Mild Cognitive Impairment

Overview

Journal Neurobiol Aging

Publisher Elsevier

Specialties Geriatrics
Neurology
Physiology

Date 2021 Jan 10

PMID 33422892

Citations 35

Authors

Farshid Sepehrband

Giuseppe Barisano

Nasim Sheikh-Bahaei

Jeiran Choupan

Ryan P Cabeen

Kirsten M Lynch

Malcolm S Crawford

Haoyu Lan

Wendy J Mack

Helena C Chui

John M Ringman

Arthur W Toga

Affiliations

Soon will be listed here.

Abstract

Vascular contributions to early cognitive decline are increasingly recognized, prompting further investigation into the nature of related changes in perivascular spaces (PVS). Using magnetic resonance imaging, we show that, compared to a cognitively normal sample, individuals with early cognitive dysfunction have altered PVS presence and distribution, irrespective of Amyloid-β. Surprisingly, we noted lower PVS presence in the anterosuperior medial temporal lobe (asMTL) (1.29 times lower PVS volume fraction in cognitively impaired individuals, p < 0.0001), which was associated with entorhinal neurofibrillary tau tangle deposition (beta (standard error) = -0.98 (0.4); p = 0.014), one of the hallmarks of early Alzheimer's disease pathology. We also observed higher PVS volume fraction in centrum semi-ovale of the white matter, but only in female participants (1.47 times higher PVS volume fraction in cognitively impaired individuals, p = 0.0011). We also observed PVS changes in participants with history of hypertension (higher in the white matter and lower in the asMTL). Our results suggest that anatomically specific alteration of the PVS is an early neuroimaging feature of cognitive impairment in aging adults, which is differentially manifested in female.

Citing Articles

Perivascular and parenchymal fluid characteristics are related to age and cognitive performance across the lifespan.

Lynch K, Custer R, Sepehrband F, Toga A, Choupan J bioRxiv. 2025; .

PMID: 40060450 PMC: 11888170. DOI: 10.1101/2024.10.14.616343.

Robust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy.

Barisano G, Iv M, Choupan J, Hayden-Gephart M EBioMedicine. 2024; 111():105523.

PMID: 39721217 PMC: 11732520. DOI: 10.1016/j.ebiom.2024.105523.

Neuroinflammation modifies the relationship between stress and perivascular spaces in an elderly population with different levels of cognitive impairment.

Sibilia F, Sheikh-Bahaei N, Mack W, Barisano G, Choupan J Front Cell Neurosci. 2024; 18:1480405.

PMID: 39610697 PMC: 11603360. DOI: 10.3389/fncel.2024.1480405.

Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits.

Engstrom A, Alitin J, Kapoor A, Dutt S, Lohman T, Sible I Alzheimers Dement. 2024; 21(1):e14396.

PMID: 39555916 PMC: 11772704. DOI: 10.1002/alz.14396.

Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology.

Han F, Lee J, Chen X, Ziontz J, Ward T, Landau S Alzheimers Dement. 2024; 20(12):8541-8555.

PMID: 39508716 PMC: 11667553. DOI: 10.1002/alz.14296.

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