Associations Among Cognitive Functions, Plasma DNA, and Diffusion Tensor Image Along the Perivascular Space (DTI-ALPS) in Patients with Parkinson's Disease

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2021 Mar 8

PMID 33680283

Citations 67

Authors

Hsiu-Ling Chen

Pei-Chin Chen

Cheng-Hsien Lu

Nai-Wen Tsai

Chiun-Chieh Yu

Kun-Hsien Chou

Yun-Ru Lai

Toshiaki Taoka

Wei-Che Lin

Affiliations

Soon will be listed here.

Abstract

Background: Parkinson's disease (PD) is a common neurodegenerative disease associated with accumulation of misfolding proteins and increased neuroinflammation, which may further impair the glymphatic system. The purpose of this study was to utilize diffusion tensor image analysis along the perivascular space (DTI-ALPS) to evaluate glymphatic system activity and its relationship with systemic oxidative stress status in PD patients.

Methods: Magnetic resonance imaging and neuropsychological tests were conducted on 25 PD patients with normal cognition (PDN), 25 PD patients with mild cognitive impairment (PD-MCI), 38 PD patients with dementia (PDD), and 47 normal controls (NC). Oxidative stress status was assessed by plasma DNA level. Differences in ALPS-index among the subgroups were assessed and further correlated with cognitive functions and plasma DNA levels.

Results: The PD-MCI and PDD groups showed significantly lower ALPS-index compared to normal controls. The ALPS-index was inversely correlated with plasma nuclear DNA, mitochondrial DNA levels, and cognitive scores.

Conclusions: Lower diffusivity along the perivascular space, represented by lower ALPS-index, indicates impairment of the glymphatic system in PD patients. The correlation between elevated plasma nuclear DNA levels and lower ALPS-index supports the notion that PD patients may exhibit increased oxidative stress associated with glymphatic system microstructural alterations.

Citing Articles

Glymphatic system: a self-purification circulation in brain.

Chen S, Wang H, Zhang L, Xi Y, Lu Y, Yu K Front Cell Neurosci. 2025; 19:1528995.

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Diffusion tensor image analysis along the perivascular space and quantitative susceptibility mapping in the diagnosis and severity assessment of Parkinson's disease.

Ni C, Chen L, Lin R, Zheng W, Cai Y, Cai G Quant Imaging Med Surg. 2025; 15(2):1411-1424.

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Glymphatic system dysfunction as a biomarker of disease progression in Parkinson's disease: neuroimaging evidence from longitudinal cohort studies.

Ren J, Xie D, Wang L, Wu Z, Lin S, Jin Q J Neurol. 2025; 272(3):196.

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Mitochondrial DNA (mtDNA) as fluid biomarker in neurodegenerative disorders: A systematic review.

Risi B, Imarisio A, Cuconato G, Padovani A, Valente E, Filosto M Eur J Neurol. 2025; 32(1):e70014.

PMID: 39831374 PMC: 11744304. DOI: 10.1111/ene.70014.

Diffusion tensor imaging along the perivascular space: the bias from crossing fibres.

Georgiopoulos C, Werlin A, Lasic S, Hall S, van Westen D, Spotorno N Brain Commun. 2024; 6(6):fcae421.

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