Effects of Beta-band and Gamma-band Rhythmic Stimulation on Motor Inhibition

Overview

Journal iScience

Publisher Cell Press

Date 2022 May 23

PMID 35602965

Authors

Inge Leunissen

Manon Van Steenkiste

Kirstin-Friederike Heise

Thiago Santos Monteiro

Kyle Dunovan

Dante Mantini

James P Coxon

Stephan P Swinnen

Affiliations

Soon will be listed here.

Abstract

To investigate whether beta oscillations are related to motor inhibition, thirty-six participants underwent two concurrent transcranial alternating current stimulation (tACS) and electroencephalography (EEG) sessions during which either beta (20 Hz) or gamma (70 Hz) stimulation was applied while participants performed a stop-signal task. In addition, we acquired magnetic resonance images to simulate the electric field during tACS. 20 Hz stimulation targeted at the pre-supplementary motor area enhanced inhibition and increased beta oscillatory power around the time of the stop-signal in trials directly following stimulation. The increase in inhibition on stop trials followed a dose-response relationship with the strength of the individually simulated electric field. Computational modeling revealed that 20 and 70 Hz stimulation had opposite effects on the braking process. These results highlight that the effects of tACS are state-dependent and demonstrate that fronto-central beta activity is causally related to successful motor inhibition, supporting its use as a functional biomarker.

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