Exploration of the Potential Mechanism of the Common Differentially Expressed Genes in Psoriasis and Atopic Dermatitis

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2022 May 19

PMID 35586812

Authors

Zhiyu Zhou

Li Meng

Yawen Cai

Wannian Yan

Yun Bai

Jia Chen

Affiliations

Soon will be listed here.

Abstract

Backgrounds: Psoriasis and atopic dermatitis are two common chronic inflammatory skin diseases that enormously deteriorate the psycho-physical and socio-economic condition of the patients. Although differential immune responses have been found to operate in the pathomechanisms of atopic dermatitis and psoriasis, the epidermal keratinocytes are the major targets in both diseases, and sometimes, they show similar clinical presentations. The skin barrier, itching, and inflammation are current and future treatment targets for both of them, but the relevant shared mechanisms of the two diseases are far from understood.

Methods: The differential analyses of GSE14905 (psoriasis) and GSE32924 (atopic dermatitis) deposited in GEO database were conducted and obtained their differential expressed genes. Moreover, PPI, functional modules, GO, and KEGG enrichment analyses were used for the further analysis. The mouse models of psoriasis and atopic dermatitis were established, and then, RT-qPCR and Western blotting assay were performed to check the abundant changes of hub genes.

Results: There are 732 differentially expressed genes in psoriasis versus nonlesional skin samples. Besides, 611 differentially expressed genes were identified in atopic dermatitis versus nonlesional skin data sets. Based on these differentially expressed genes, we predicted their joint and individual protein-protein interaction networks and functional modules in both psoriasis and atopic dermatitis. Through the PPI network of genes, we calculated the hub nodes and do the GO and KEGG enrichment analysis of overlapped genes of psoriasis and atopic dermatitis, which suggested there were some terms like "positive regulation of interleukin-12 production," "centromeric region," and "TNF signaling pathway."

Conclusion: We constructed the predicted PPI networks and functional modules related to psoriasis and atopic dermatitis and distinguished the key candidate target genes , , and in the diagnosis and therapy of similar pathogenesis.

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References

Silverberg J, Garg N, Paller A, Fishbein A, Zee P . Sleep disturbances in adults with eczema are associated with impaired overall health: a US population-based study. J Invest Dermatol. 2014; 135(1):56-66. DOI: 10.1038/jid.2014.325. View

Nestle F, Kaplan D, Barker J . Psoriasis. N Engl J Med. 2009; 361(5):496-509. DOI: 10.1056/NEJMra0804595. View

von Mering C, Huynen M, Jaeggi D, Schmidt S, Bork P, Snel B . STRING: a database of predicted functional associations between proteins. Nucleic Acids Res. 2003; 31(1):258-61. PMC: 165481. DOI: 10.1093/nar/gkg034. View

Ritchie M, Phipson B, Wu D, Hu Y, Law C, Shi W . limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015; 43(7):e47. PMC: 4402510. DOI: 10.1093/nar/gkv007. View

He X, Zhang J . Why do hubs tend to be essential in protein networks?. PLoS Genet. 2006; 2(6):e88. PMC: 1473040. DOI: 10.1371/journal.pgen.0020088. View

Danielsen K, Olsen A, Wilsgaard T, Furberg A . Is the prevalence of psoriasis increasing? A 30-year follow-up of a population-based cohort. Br J Dermatol. 2013; 168(6):1303-10. DOI: 10.1111/bjd.12230. View

Vakharia P, Chopra R, Sacotte R, Patel K, Singam V, Patel N . Burden of skin pain in atopic dermatitis. Ann Allergy Asthma Immunol. 2017; 119(6):548-552.e3. PMC: 5726579. DOI: 10.1016/j.anai.2017.09.076. View

Zhang P, Wu M . A clinical review of phototherapy for psoriasis. Lasers Med Sci. 2017; 33(1):173-180. PMC: 5756569. DOI: 10.1007/s10103-017-2360-1. View

Bylund S, Kobyletzki L, Svalstedt M, Svensson A . Prevalence and Incidence of Atopic Dermatitis: A Systematic Review. Acta Derm Venereol. 2020; 100(12):adv00160. PMC: 9189744. DOI: 10.2340/00015555-3510. View

10.

Kanehisa M, Goto S . KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 1999; 28(1):27-30. PMC: 102409. DOI: 10.1093/nar/28.1.27. View

11.

Rachakonda T, Schupp C, Armstrong A . Psoriasis prevalence among adults in the United States. J Am Acad Dermatol. 2014; 70(3):512-6. DOI: 10.1016/j.jaad.2013.11.013. View

12.

Krueger G, Ellis C . Psoriasis--recent advances in understanding its pathogenesis and treatment. J Am Acad Dermatol. 2005; 53(1 Suppl 1):S94-100. DOI: 10.1016/j.jaad.2005.04.035. View

13.

Guttman-Yassky E, Krueger J . Atopic dermatitis and psoriasis: two different immune diseases or one spectrum?. Curr Opin Immunol. 2017; 48:68-73. DOI: 10.1016/j.coi.2017.08.008. View

14.

Chiricozzi A, Pimpinelli N, Ricceri F, Bagnoni G, Bartoli L, Bellini M . Treatment of psoriasis with topical agents: Recommendations from a Tuscany Consensus. Dermatol Ther. 2017; 30(6). DOI: 10.1111/dth.12549. View

15.

Ronnstad A, Halling-Overgaard A, Hamann C, Skov L, Egeberg A, Thyssen J . Association of atopic dermatitis with depression, anxiety, and suicidal ideation in children and adults: A systematic review and meta-analysis. J Am Acad Dermatol. 2018; 79(3):448-456.e30. DOI: 10.1016/j.jaad.2018.03.017. View

16.

Ha H, Debnath B, Neamati N . Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases. Theranostics. 2017; 7(6):1543-1588. PMC: 5436513. DOI: 10.7150/thno.15625. View

17.

Yu G, Wang L, Han Y, He Q . clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012; 16(5):284-7. PMC: 3339379. DOI: 10.1089/omi.2011.0118. View

18.

Menter A, Griffiths C . Current and future management of psoriasis. Lancet. 2007; 370(9583):272-284. DOI: 10.1016/S0140-6736(07)61129-5. View

19.

Guttman-Yassky E, Waldman A, Ahluwalia J, Ong P, Eichenfield L . Atopic dermatitis: pathogenesis. Semin Cutan Med Surg. 2017; 36(3):100-103. DOI: 10.12788/j.sder.2017.036. View

20.

Shaker M, Murray R, Mann J . The ins and outs of an 'outside-in' view of allergies: atopic dermatitis and allergy prevention. Curr Opin Pediatr. 2018; 30(4):576-581. DOI: 10.1097/MOP.0000000000000646. View