Platelet Activation: a Promoter for Psoriasis and Its Comorbidity, Cardiovascular Disease

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2023 Sep 1

PMID 37654493

Authors

Ziqi Jiang

Xiaoran Jiang

Aijun Chen

Wenyan He

Affiliations

Soon will be listed here.

Abstract

Psoriasis is a chronic inflammatory skin disease with a prevalence of 0.14% to 1.99%. The underlying pathology is mainly driven by the abnormal immune responses including activation of Th1, Th17, Th22 cells and secretion of cytokines. Patients with psoriasis are more likely to develop cardiovascular disease (CVD) which has been well recognized as a comorbidity of psoriasis. As mediators of hemostasis and thromboinflammation, platelets play an important part in CVD. However, less is known about their pathophysiological contribution to psoriasis and psoriasis-associated CVD. A comprehensive understanding of the role of platelet activation in psoriasis might pave the path for more accurate prediction of cardiovascular (CV) risk and provide new strategies for psoriasis management, which alleviates the increased CV burden associated with psoriasis. Here we review the available evidence about the biomarkers and mechanisms of platelet activation in psoriasis and the role of platelet activation in intriguing the common comorbidity, CVD. We further discussed the implications and efficacy of antiplatelet therapies in the treatment of psoriasis and prevention of psoriasis-associated CVD.

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References

Unal M . Platelet mass index is increased in psoriasis. A possible link between psoriasis and atherosclerosis. Arch Med Sci Atheroscler Dis. 2017; 1(1):e145-e149. PMC: 5421536. DOI: 10.5114/amsad.2016.64444. View

Garbaraviciene J, Diehl S, Varwig D, Bylaite M, Ackermann H, Ludwig R . Platelet P-selectin reflects a state of cutaneous inflammation: possible application to monitor treatment efficacy in psoriasis. Exp Dermatol. 2010; 19(8):736-41. DOI: 10.1111/j.1600-0625.2010.01095.x. View

Morrell C, Aggrey A, Chapman L, Modjeski K . Emerging roles for platelets as immune and inflammatory cells. Blood. 2014; 123(18):2759-67. PMC: 4007605. DOI: 10.1182/blood-2013-11-462432. View

Parisi R, Iskandar I, Kontopantelis E, Augustin M, Griffiths C, Ashcroft D . National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study. BMJ. 2020; 369:m1590. PMC: 7254147. DOI: 10.1136/bmj.m1590. View

Capo A, Di Nicola M, Auriemma M, Piaserico S, Cuccurullo C, Santilli F . Mean platelet volume variation after biologic therapy in psoriasis and psoriatic arthritis. Eur J Dermatol. 2014; 24(1):133-5. DOI: 10.1684/ejd.2014.2269. View

Friedrich E, Tager A, Liu E, Pettersson A, Owman C, Munn L . Mechanisms of leukotriene B4--triggered monocyte adhesion. Arterioscler Thromb Vasc Biol. 2003; 23(10):1761-7. DOI: 10.1161/01.ATV.0000092941.77774.3C. View

Takeshita J, Mohler E, Krishnamoorthy P, Moore J, Rogers W, Zhang L . Endothelial cell-, platelet-, and monocyte/macrophage-derived microparticles are elevated in psoriasis beyond cardiometabolic risk factors. J Am Heart Assoc. 2014; 3(1):e000507. PMC: 3959700. DOI: 10.1161/JAHA.113.000507. View

Sreeramkumar V, Adrover J, Ballesteros I, Cuartero M, Rossaint J, Bilbao I . Neutrophils scan for activated platelets to initiate inflammation. Science. 2014; 346(6214):1234-8. PMC: 4280847. DOI: 10.1126/science.1256478. View

Singh T, Schon M, Wallbrecht K, Gruber-Wackernagel A, Wang X, Wolf P . Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis. PLoS One. 2013; 8(1):e51752. PMC: 3546056. DOI: 10.1371/journal.pone.0051752. View

10.

Grundy S, Stone N, Bailey A, Beam C, Birtcher K, Blumenthal R . 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2018; 139(25):e1082-e1143. PMC: 7403606. DOI: 10.1161/CIR.0000000000000625. View

11.

Raghavan V, Radha R, Rao R, Kuberan A . A Correlative Study between Platelet Count, Mean Platelet Volume and Red Cell Distribution Width with the Disease Severity Index in Psoriasis Patients. J Clin Diagn Res. 2017; 11(9):EC13-EC16. PMC: 5713737. DOI: 10.7860/JCDR/2017/31172.10639. View

12.

Antiga E, Bonciolini V, Volpi W, Del Bianco E, Caproni M . Oral Curcumin (Meriva) Is Effective as an Adjuvant Treatment and Is Able to Reduce IL-22 Serum Levels in Patients with Psoriasis Vulgaris. Biomed Res Int. 2015; 2015:283634. PMC: 4450233. DOI: 10.1155/2015/283634. View

13.

Zhao L, Liu D, Liu B, Hu H, Cui W . Effects of atorvastatin on ADP-, arachidonic acid-, collagen-, and epinephrine-induced platelet aggregation. J Int Med Res. 2016; 45(1):82-88. PMC: 5536584. DOI: 10.1177/0300060516675681. View

14.

Tamagawa-Mineoka R, Katoh N, Kishimoto S . Platelet activation in patients with psoriasis: increased plasma levels of platelet-derived microparticles and soluble P-selectin. J Am Acad Dermatol. 2009; 62(4):621-6. DOI: 10.1016/j.jaad.2009.06.053. View

15.

Violi F, Carnevale R, Pastori D, Pignatelli P . Antioxidant and antiplatelet effects of atorvastatin by Nox2 inhibition. Trends Cardiovasc Med. 2013; 24(4):142-8. DOI: 10.1016/j.tcm.2013.09.006. View

16.

Garshick M, Tawil M, Barrett T, Salud-Gnilo C, Eppler M, Lee A . Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis via COX-1. Arterioscler Thromb Vasc Biol. 2020; 40(5):1340-1351. PMC: 7180109. DOI: 10.1161/ATVBAHA.119.314008. View

17.

An I, Aksoy M, Ayhan E, Ozturk M . The effect of secukinumab treatment on inflammatory parameters in patients with psoriasis: A multicentre restrospective study. Int J Clin Pract. 2021; 75(6):e14114. DOI: 10.1111/ijcp.14114. View

18.

Medina-Leyte D, Zepeda-Garcia O, Dominguez-Perez M, Gonzalez-Garrido A, Villarreal-Molina T, Jacobo-Albavera L . Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches. Int J Mol Sci. 2021; 22(8). PMC: 8068178. DOI: 10.3390/ijms22083850. View

19.

BURSTEIN S, Peng J, Friese P, Wolf R, Harrison P, Downs T . Cytokine-induced alteration of platelet and hemostatic function. Stem Cells. 1996; 14 Suppl 1:154-62. DOI: 10.1002/stem.5530140720. View

20.

Ridker P, Cushman M, Stampfer M, Tracy R, Hennekens C . Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997; 336(14):973-9. DOI: 10.1056/NEJM199704033361401. View