A Degenerate Metal-Templated Catalytic System with Redundant Functional Groups for the Asymmetric Aldol Reaction

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2022 May 18

PMID 35583468

Authors

Alba Sors-Vendrell

Albert Ortiz

Diego Meneses

Ignacio Alfonso

Jordi Sola

Ciril Jimeno

Affiliations

Soon will be listed here.

Abstract

A degenerate zinc-templated catalytic system containing two bipyridine ligands with redundant functional groups for either enamine or hydrogen bond formation was applied to the asymmetric aldol reaction. This concept led to both a higher probability of reaction and rate acceleration. Thus, the catalyst loading could be decreased to a remarkable 2 mol % in what we think is a general approach.

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