The Direct Catalytic Asymmetric Aldol Reaction

Overview

Journal Chem Soc Rev

Specialty Chemistry

Date 2010 Apr 27

PMID 20419212

Citations 73

Authors

Barry M Trost

Cheyenne S Brindle

Affiliations

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Abstract

Asymmetric aldol reactions are a powerful method for the construction of carbon-carbon bonds in an enantioselective fashion. Historically this reaction has been performed in a stoichiometric fashion to control the various aspects of chemo-, diastereo-, regio- and enantioselectivity, however, a more atom economical approach would unite high selectivity with the use of only a catalytic amount of a chiral promoter. This critical review documents the development of direct catalytic asymmetric aldol methodologies, including organocatalytic and metal-based strategies. New methods have improved the reactivity, selectivity and substrate scope of the direct aldol reaction and enabled the synthesis of complex molecular targets (357 references).

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