ILCs and Allergy

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2022 May 14

PMID 35567742

Authors

Hiroki Kabata

Yasutaka Motomura

Tsuyoshi Kiniwa

Tetsuro Kobayashi

Kazuyo Moro

Affiliations

Soon will be listed here.

Abstract

The recent discovery of new innate lymphoid cells (ILCs) has revolutionized the field of allergies. Since most allergic diseases induce a type 2 immune response, Th2 cells, which produce IL-4, IL-5, and IL-13 in an antigen-dependent manner, in addition to basophils and mast cells which are activated by antigen-specific IgE, are thought to play a major role in the pathogenesis. However, since group 2 innate lymphoid cells (ILC2s) produce type 2 cytokines (i.e., IL-2, IL-4, IL-5, IL-6, IL-9, IL-13, GM-CSF, and amphiregulin) in response to various cytokines, including IL-33 in the surrounding environment, the possibility has emerged that there are two types of allergies: allergies induced in an antigen-dependent manner by Th2 cells and allergies induced in an antigen-independent manner by ILC2s. In order to make an impact on the increasing incidence of allergic diseases in the world, it is essential to research and develop new treatments that focus not only on Th2 cells but also on ILC2s. In this chapter, the role of ILCs in allergic diseases, which has rapidly changed with the discovery of ILCs, is discussed, focusing mainly on ILC2s.

Citing Articles

CAVO Inhibits Airway Inflammation and ILC2s in OVA-Induced Murine Asthma Mice.

Huang F, Tong X, Hu C, Zhang Q, Wei Y, Hu M Biomed Res Int. 2024; 2023:8783078.

PMID: 39282108 PMC: 11401656. DOI: 10.1155/2023/8783078.

Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances.

Zhao L, Jin S, Wang S, Zhang Z, Wang X, Chen Z Signal Transduct Target Ther. 2024; 9(1):225.

PMID: 39198425 PMC: 11358547. DOI: 10.1038/s41392-024-01947-5.

JACQLQ subjective symptom questionnaire score and clinical test results for patients with allergic conjunctival disease.

Yamana Y, Yamana S, Uchio E Sci Rep. 2024; 14(1):16235.

PMID: 39004666 PMC: 11247079. DOI: 10.1038/s41598-024-67117-3.

Prediction of distinct populations of innate lymphoid cells by transcriptional profiles.

Dong H, Du Z, Ma H, Zhou Z, Yang H, Wang Z Front Genet. 2023; 14:1227452.

PMID: 37719706 PMC: 10500302. DOI: 10.3389/fgene.2023.1227452.

Role of Innate Immunity in Allergic Contact Dermatitis: An Update.

Yamaguchi H, Yamaguchi Y, Peeva E Int J Mol Sci. 2023; 24(16).

PMID: 37629154 PMC: 10455292. DOI: 10.3390/ijms241612975.

References

Monticelli L, Sonnenberg G, Abt M, Alenghat T, Ziegler C, Doering T . Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol. 2011; 12(11):1045-54. PMC: 3320042. DOI: 10.1031/ni.2131. View

Yudanin N, Schmitz F, Flamar A, Thome J, Tait Wojno E, Moeller J . Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity. Immunity. 2019; 50(2):505-519.e4. PMC: 6594374. DOI: 10.1016/j.immuni.2019.01.012. View

Marquardt N, Kekalainen E, Chen P, Kvedaraite E, Wilson J, Ivarsson M . Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69CD56 cells. J Allergy Clin Immunol. 2016; 139(4):1321-1330.e4. DOI: 10.1016/j.jaci.2016.07.043. View

Silver J, Kearley J, Copenhaver A, Sanden C, Mori M, Yu L . Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs. Nat Immunol. 2016; 17(6):626-35. PMC: 5345745. DOI: 10.1038/ni.3443. View

Kim H, Lee H, Chang Y, Pichavant M, Shore S, Fitzgerald K . Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat Med. 2013; 20(1):54-61. PMC: 3912313. DOI: 10.1038/nm.3423. View

Klein Wolterink R, Kleinjan A, van Nimwegen M, Bergen I, de Bruijn M, Levani Y . Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma. Eur J Immunol. 2012; 42(5):1106-16. DOI: 10.1002/eji.201142018. View

Bartemes K, Iijima K, Kobayashi T, Kephart G, Mckenzie A, Kita H . IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J Immunol. 2011; 188(3):1503-13. PMC: 3262877. DOI: 10.4049/jimmunol.1102832. View

Halim T, Krauss R, Sun A, Takei F . Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity. 2012; 36(3):451-63. DOI: 10.1016/j.immuni.2011.12.020. View

10.

Arae K, Ikutani M, Horiguchi K, Yamaguchi S, Okada Y, Sugiyama H . Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin. Sci Rep. 2021; 11(1):5913. PMC: 7960735. DOI: 10.1038/s41598-021-85277-4. View

11.

Kim H, Chang Y, Subramanian S, Lee H, Albacker L, Matangkasombut P . Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity. J Allergy Clin Immunol. 2011; 129(1):216-27.e1-6. PMC: 3246069. DOI: 10.1016/j.jaci.2011.10.036. View

12.

Han M, Rajput C, Hong J, Lei J, Hinde J, Wu Q . The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice. J Immunol. 2017; 199(4):1308-1318. PMC: 5548608. DOI: 10.4049/jimmunol.1700216. View

13.

Chang Y, Kim H, Albacker L, Baumgarth N, McKenzie A, Smith D . Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat Immunol. 2011; 12(7):631-8. PMC: 3417123. DOI: 10.1038/ni.2045. View

14.

Kouzaki H, Iijima K, Kobayashi T, OGrady S, Kita H . The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol. 2011; 186(7):4375-87. PMC: 3062674. DOI: 10.4049/jimmunol.1003020. View

15.

Cayrol C, Duval A, Schmitt P, Roga S, Camus M, Stella A . Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33. Nat Immunol. 2018; 19(4):375-385. DOI: 10.1038/s41590-018-0067-5. View

16.

Furusawa J, Moro K, Motomura Y, Okamoto K, Zhu J, Takayanagi H . Critical role of p38 and GATA3 in natural helper cell function. J Immunol. 2013; 191(4):1818-26. PMC: 3765427. DOI: 10.4049/jimmunol.1300379. View

17.

Kabata H, Moro K, Koyasu S . The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms. Immunol Rev. 2018; 286(1):37-52. DOI: 10.1111/imr.12706. View

18.

Hammad H, Lambrecht B . The basic immunology of asthma. Cell. 2021; 184(6):1469-1485. DOI: 10.1016/j.cell.2021.02.016. View

19.

Lambrecht B, Hammad H . The immunology of asthma. Nat Immunol. 2014; 16(1):45-56. DOI: 10.1038/ni.3049. View

20.

Torgerson D, Ampleford E, Chiu G, Gauderman W, Gignoux C, Graves P . Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011; 43(9):887-92. PMC: 3445408. DOI: 10.1038/ng.888. View

21.

Prefontaine D, Lajoie-Kadoch S, Foley S, Audusseau S, Olivenstein R, Halayko A . Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. J Immunol. 2009; 183(8):5094-103. DOI: 10.4049/jimmunol.0802387. View