Innate Lymphoid Cells Promote Lung-tissue Homeostasis After Infection with Influenza Virus

Overview

Journal Nat Immunol

Date 2011 Sep 28

PMID 21946417

Citations 826

Authors

Laurel A Monticelli

Gregory F Sonnenberg

Michael C Abt

Theresa Alenghat

Carly G K Ziegler

Travis A Doering

Jill M Angelosanto

Brian J Laidlaw

Cliff Y Yang

Taheri Sathaliyawala

Masaru Kubota

Damian Turner

Joshua M Diamond

Ananda W Goldrath

Donna L Farber

Ronald G Collman

E John Wherry

David Artis

Affiliations

Soon will be listed here.

Abstract

Innate lymphoid cells (ILCs), a heterogeneous cell population, are critical in orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue homeostasis at other mucosal sites remains poorly characterized. Here we identify a population of lung-resident ILCs in mice and humans that expressed the alloantigen Thy-1 (CD90), interleukin 2 (IL-2) receptor a-chain (CD25), IL-7 receptor a-chain (CD127) and the IL-33 receptor subunit T1-ST2. Notably, mouse ILCs accumulated in the lung after infection with influenza virus, and depletion of ILCs resulted in loss of airway epithelial integrity, diminished lung function and impaired airway remodeling. These defects were restored by administration of the lung ILC product amphiregulin. Collectively, our results demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus.

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