Preparation of Distant Quaternary Carbon Stereocenters by Double Selective Ring-Opening of 1,1-Biscyclopropyl Methanol Derivatives

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2022 May 6

PMID 35521738

Authors

Yogesh Siddaraju

Juliette Sabbatani

Anthony Cohen

Ilan Marek

Affiliations

Soon will be listed here.

Abstract

The diastereoselective double carbometalation reaction of cyclopropenes provides, in a single-pot operation, two ω-ene-[1,1]-bicyclopropyl ester derivatives. One regioisomer then undergoes a Pd-catalyzed addition of aryl iodide to provide skipped dienes possessing several distant stereocenters including two congested quaternary carbon centers with excellent diastereoselectivity.

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