Opening Up the Toolbox: Synthesis and Mechanisms of Phosphoramidates

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Aug 23

PMID 32823507

Citations 6

Authors

Emeka J Itumoh

Shailja Data

Erin M Leitao

Affiliations

Soon will be listed here.

Abstract

This review covers the main synthetic routes to and the corresponding mechanisms of phosphoramidate formation. The synthetic routes can be separated into six categories: salt elimination, oxidative cross-coupling, azide, reduction, hydrophosphinylation, and phosphoramidate-aldehyde-dienophile (PAD). Examples of some important compounds synthesized through these routes are provided. As an important class of organophosphorus compounds, the applications of phosphoramidate compounds, are also briefly introduced.

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