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COVID-19 Vaccine Effectiveness Against Severe Disease from SARS-CoV-2 Omicron BA.1 and BA.2 Subvariants - Surveillance Results from Southern Sweden, December 2021 to March 2022

Overview
Journal Euro Surveill
Date 2022 May 6
PMID 35514304
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Abstract

We compared vaccine effectiveness against severe COVID-19 between December 2021 and March 2022 when Omicron BA.1 and BA.2 were the dominating SARS-CoV-2 variants in Scania county, Sweden. Effectiveness remained above 80% after the transition from BA.1 to BA.2 among people with at least three vaccine doses but the point estimate decreased markedly to 54% among those with only two doses. Protection from prior infection was also lower after the transition to BA.2. Booster vaccination seems necessary to maintain sufficient protection.

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