The Origins and Roles of Osteoclasts in Bone Development, Homeostasis and Repair

Overview

Journal Development

Specialty Biology

Date 2022 May 3

PMID 35502779

Authors

Yasuhito Yahara

Tuyet Nguyen

Koji Ishikawa

Katsuhiko Kamei

Benjamin A Alman

Affiliations

Soon will be listed here.

Abstract

The mechanisms underlying bone development, repair and regeneration are reliant on the interplay and communication between osteoclasts and other surrounding cells. Osteoclasts are multinucleated monocyte lineage cells with resorptive abilities, forming the bone marrow cavity during development. This marrow cavity, essential to hematopoiesis and osteoclast-osteoblast interactions, provides a setting to investigate the origin of osteoclasts and their multi-faceted roles. This Review examines recent developments in the embryonic understanding of osteoclast origin, as well as interactions within the immune environment to regulate normal and pathological bone development, homeostasis and repair.

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