Application of Antioxidant Compounds in Bone Defect Repair

Overview

Journal Antioxidants (Basel)

Date 2024 Jul 27

PMID 39061858

Authors

Jiajia Wang

Yubing Zhang

Qingming Tang

Yinan Zhang

Ying Yin

Lili Chen

Affiliations

Soon will be listed here.

Abstract

Bone defects caused by trauma, tumor resection, and infections are significant clinical challenges. Excessive reactive oxygen species (ROS) usually accumulate in the defect area, which may impair the function of cells involved in bone formation, posing a serious challenge for bone repair. Due to the potent ROS scavenging ability, as well as potential anti-inflammatory and immunomodulatory activities, antioxidants play an indispensable role in the maintenance and protection of bone health and have gained increasing attention in recent years. This narrative review aims to give an overview of the main research directions on the application of antioxidant compounds in bone defect repair over the past decade. In addition, the positive effects of various antioxidants and their biomaterial delivery systems in bone repair are summarized to provide new insights for exploring antioxidant-based strategies for bone defect repair.

Citing Articles

Oxidation-responsive, settable bone substitute composites for regenerating critically-sized bone defects.

Dos Santos R, Ahmed A, Hunn B, Addison A, Marques D, Bruce K Biomater Sci. 2025; .

PMID: 40012338 PMC: 11877281. DOI: 10.1039/d4bm01345j.

Role of oxidative stress in impaired type II diabetic bone repair: scope for antioxidant therapy intervention?.

Li P, Alenazi K, Dally J, Woods E, Waddington R, Moseley R Front Dent Med. 2025; 5:1464009.

PMID: 39917650 PMC: 11797775. DOI: 10.3389/fdmed.2024.1464009.

Evaluation of Oxidative Stress and Cellular Immunity in Grades III-IV Knee Osteoarthritis.

Aydin M, Alp Avci G, Yilmaz U, Aydin T, Avci E Arch Bone Jt Surg. 2024; 12(12):840-845.

PMID: 39720550 PMC: 11664745. DOI: 10.22038/ABJS.2024.78412.3612.

Effect of nHA/CS/PLGA delivering adipose stem cell-derived exosomes and bone marrow stem cells on bone healing-in vitro and in vivo studies.

Wang T, Guo S, Zhang Y Sci Rep. 2024; 14(1):27502.

PMID: 39528545 PMC: 11555374. DOI: 10.1038/s41598-024-76672-8.

References

Ye Y, Zhong H, Huang S, Lai W, Huang Y, Sun C . Reactive Oxygen Species Scavenging Hydrogel Regulates Stem Cell Behavior and Promotes Bone Healing in Osteoporosis. Tissue Eng Regen Med. 2023; 20(6):981-992. PMC: 10519916. DOI: 10.1007/s13770-023-00561-w. View

Huang L, Lu S, Bian M, Wang J, Yu J, Ge J . Punicalagin attenuates TNF-α-induced oxidative damage and promotes osteogenic differentiation of bone mesenchymal stem cells by activating the Nrf2/HO-1 pathway. Exp Cell Res. 2023; 430(1):113717. DOI: 10.1016/j.yexcr.2023.113717. View

Siddiqui J, Partridge N . Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement. Physiology (Bethesda). 2016; 31(3):233-45. PMC: 6734079. DOI: 10.1152/physiol.00061.2014. View

Chattopadhyay R, Raghavan S, Rao G . Resolvin D1 via prevention of ROS-mediated SHP2 inactivation protects endothelial adherens junction integrity and barrier function. Redox Biol. 2017; 12:438-455. PMC: 5357675. DOI: 10.1016/j.redox.2017.02.023. View

Romagnoli C, Marcucci G, Favilli F, Zonefrati R, Mavilia C, Galli G . Role of GSH/GSSG redox couple in osteogenic activity and osteoclastogenic markers of human osteoblast-like SaOS-2 cells. FEBS J. 2012; 280(3):867-79. DOI: 10.1111/febs.12075. View

Naganuma T, Traversa E . Stability of the Ce3+ valence state in cerium oxide nanoparticle layers. Nanoscale. 2012; 4(16):4950-3. DOI: 10.1039/c2nr30406f. View

Guo J, Yang X, Chen J, Wang C, Kang Y, Jiang T . Accelerated Bone Regeneration by an Astaxanthin-Modified Antioxidant Aerogel through Relieving Oxidative Stress via the NRF2 Signaling Pathway. ACS Biomater Sci Eng. 2022; 8(10):4524-4534. DOI: 10.1021/acsbiomaterials.2c00596. View

Ding W, Zhou Q, Lu Y, Wei Q, Tang H, Zhang D . ROS-scavenging hydrogel as protective carrier to regulate stem cells activity and promote osteointegration of 3D printed porous titanium prosthesis in osteoporosis. Front Bioeng Biotechnol. 2023; 11:1103611. PMC: 9887181. DOI: 10.3389/fbioe.2023.1103611. View

Afzal F, Polak J, Buttery L . Endothelial nitric oxide synthase in the control of osteoblastic mineralizing activity and bone integrity. J Pathol. 2004; 202(4):503-10. DOI: 10.1002/path.1536. View

10.

Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S . SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress. Cell Death Differ. 2017; 25(2):229-240. PMC: 5762839. DOI: 10.1038/cdd.2017.144. View

11.

Bai X, Lu D, Bai J, Zheng H, Ke Z, Li X . Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun. 2004; 314(1):197-207. DOI: 10.1016/j.bbrc.2003.12.073. View

12.

Wang H, Wang D, Huangfu H, Chen S, Qin Q, Ren S . Highly efficient photothermal branched Au-Ag nanoparticles containing procyanidins for synergistic antibacterial and anti-inflammatory immunotherapy. Biomater Sci. 2023; 11(4):1335-1349. DOI: 10.1039/d2bm01212j. View

13.

Russo C, Ferro Y, Maurotti S, Salvati M, Mazza E, Pujia R . Lycopene and bone: an in vitro investigation and a pilot prospective clinical study. J Transl Med. 2020; 18(1):43. PMC: 6990577. DOI: 10.1186/s12967-020-02238-7. View

14.

Gao X, Al-Baadani M, Wu M, Tong N, Shen X, Ding X . Study on the Local Anti-Osteoporosis Effect of Polaprezinc-Loaded Antioxidant Electrospun Membrane. Int J Nanomedicine. 2022; 17:17-29. PMC: 8743381. DOI: 10.2147/IJN.S341216. View

15.

Sies H, Jones D . Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol. 2020; 21(7):363-383. DOI: 10.1038/s41580-020-0230-3. View

16.

Chen S, Yu Y, Xie S, Liang D, Shi W, Chen S . Local H release remodels senescence microenvironment for improved repair of injured bone. Nat Commun. 2023; 14(1):7783. PMC: 10682449. DOI: 10.1038/s41467-023-43618-z. View

17.

Akcan R, Aydogan H, Yildirim M, Tastekin B, Saglam N . Nanotoxicity: a challenge for future medicine. Turk J Med Sci. 2020; 50(4):1180-1196. PMC: 7379444. DOI: 10.3906/sag-1912-209. View

18.

Ray P, Huang B, Tsuji Y . Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 2012; 24(5):981-90. PMC: 3454471. DOI: 10.1016/j.cellsig.2012.01.008. View

19.

vant Hof R, Ralston S . Nitric oxide and bone. Immunology. 2001; 103(3):255-61. PMC: 1783253. DOI: 10.1046/j.1365-2567.2001.01261.x. View

20.

Carbone E, Rajpura K, Allen B, Cheng E, Ulery B, Lo K . Osteotropic nanoscale drug delivery systems based on small molecule bone-targeting moieties. Nanomedicine. 2016; 13(1):37-47. DOI: 10.1016/j.nano.2016.08.015. View