LEAP2 Reduces Postprandial Glucose Excursions and Food Intake in Healthy Men

Overview

Journal Cell Rep Med

Publisher Cell Press

Specialties Biology
General Medicine

Date 2022 May 2

PMID 35492241

Authors

Christoffer A Hagemann

Malene S Jensen

Stephanie Holm

Laerke S Gasbjerg

Sarah Byberg

Kirsa Skov-Jeppesen

Bolette Hartmann

Jens J Holst

Flemming Dela

Tina Vilsboll

Mikkel B Christensen

Birgitte Holst

Filip K Knop

Affiliations

Soon will be listed here.

Abstract

The gastric hormone ghrelin stimulates food intake and increases plasma glucose through activation of the growth hormone secretagogue receptor (GHSR). Liver-expressed antimicrobial peptide 2 (LEAP2) has been proposed to inhibit actions of ghrelin through inverse effects on GHSR activity. Here, we investigate the effects of exogenous LEAP2 on postprandial glucose metabolism and food intake in a randomized, double-blind, placebo-controlled, crossover trial of 20 healthy men. We report that LEAP2 infusion lowers postprandial plasma glucose and growth hormone concentrations and decreases food intake during an meal test. In wild-type mice, plasma glucose and food intake are reduced by LEAP2 dosing, but not in GHSR-null mice, pointing to GHSR as a potential mediator of LEAP2's glucoregulatory and appetite-suppressing effects in mice.

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