Erebosis, a New Cell Death Mechanism During Homeostatic Turnover of Gut Enterocytes

Overview

Journal PLoS Biol

Specialty Biology

Date 2022 Apr 25

PMID 35468130

Authors

Hanna M Ciesielski

Hiroshi Nishida

Tomomi Takano

Aya Fukuhara

Tetsuhisa Otani

Yuko Ikegawa

Morihiro Okada

Takashi Nishimura

Mikio Furuse

Sa Kan Yoo

Affiliations

Soon will be listed here.

Abstract

Many adult tissues are composed of differentiated cells and stem cells, each working in a coordinated manner to maintain tissue homeostasis during physiological cell turnover. Old differentiated cells are believed to typically die by apoptosis. Here, we discovered a previously uncharacterized, new phenomenon, which we name erebosis based on the ancient Greek word erebos ("complete darkness"), in the gut enterocytes of adult Drosophila. Cells that undergo erebosis lose cytoskeleton, cell adhesion, organelles and fluorescent proteins, but accumulate Angiotensin-converting enzyme (Ance). Their nuclei become flat and occasionally difficult to detect. Erebotic cells do not have characteristic features of apoptosis, necrosis, or autophagic cell death. Inhibition of apoptosis prevents neither the gut cell turnover nor erebosis. We hypothesize that erebosis is a cell death mechanism for the enterocyte flux to mediate tissue homeostasis in the gut.

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