Tetsuhisa Otani
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Explore the profile of Tetsuhisa Otani including associated specialties, affiliations and a list of published articles.
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28
Citations
734
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Recent Articles
1.
Kuno S, Nakamura R, Otani T, Togashi H
Cell Rep
. 2025 Feb;
:115335.
PMID: 40015268
In epithelial cells, cell-cell adhesion is mediated by the apical junctional complex (AJC), which consists of tight junctions (TJs) and adherens junctions (AJs) aligned from the apical to the basal...
2.
Koyama H, Ito A, Okumura H, Otani T, Nakamura K, Fujimori T
J Theor Biol
. 2025 Feb;
604:112070.
PMID: 39978539
Measurement of mechanical forces of cell-cell interactions is important for studying the emergence of diverse three-dimensional morphologies of multicellular organisms. We previously reported an image-based statistical method for inferring effective...
3.
Deguchi E, Lin S, Hirayama D, Matsuda K, Tanave A, Sumiyama K, et al.
Cell Rep
. 2024 Nov;
43(11):114986.
PMID: 39546398
Canonical epidermal growth factor (EGF) receptor (EGFR) activation involves the binding of seven EGFR ligands (EGFRLs); however, their extracellular dynamics remain elusive. Here, employing fluorescent probes and a tool for...
4.
Deguchi E, Lin S, Hirayama D, Matsuda K, Tanave A, Sumiyama K, et al.
bioRxiv
. 2024 Oct;
PMID: 39399773
Epidermal growth factor receptor ligands (EGFRLs) consist of seven proteins. In stark contrast to the amassed knowledge concerning the epidermal growth factor receptors themselves, the extracellular dynamics of individual EGFRLs...
5.
Sugimura K, Otani T
Curr Opin Cell Biol
. 2024 Sep;
91:102427.
PMID: 39332144
Epithelial cells adhere to each other via intercellular junctions that can be classified into bicellular junctions and tricellular contacts (vertices). Epithelial morphogenesis involves cell rearrangement and requires remodeling of bicellular...
6.
Koyama H, Okumura H, Otani T, Ito A, Nakamura K, Kato K, et al.
Front Cell Dev Biol
. 2024 Aug;
12:1414601.
PMID: 39105171
Measuring mechanical forces of cell-cell interactions is important for studying morphogenesis in multicellular organisms. We previously reported an image-based statistical method for inferring effective mechanical potentials of pairwise cell-cell interactions...
7.
Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex
Nguyen T, Otani T, Tsutsumi M, Kinoshita N, Fujiwara S, Nemoto T, et al.
J Cell Biol
. 2024 Mar;
223(5).
PMID: 38517380
Epithelia must be able to resist mechanical force to preserve tissue integrity. While intercellular junctions are known to be important for the mechanical resistance of epithelia, the roles of tight...
8.
Koyama H, Okumura H, Ito A, Nakamura K, Otani T, Kato K, et al.
PLoS Comput Biol
. 2023 Aug;
19(8):e1011306.
PMID: 37549166
Mechanical forces are critical for the emergence of diverse three-dimensional morphologies of multicellular systems. However, it remains unclear what kind of mechanical parameters at cellular level substantially contribute to tissue...
9.
Miyazaki S, Otani T, Sugihara K, Fujimori T, Furuse M, Miura T
iScience
. 2023 May;
26(5):106594.
PMID: 37250331
It has been reported that the MDCK cell tight junction shows stochastic fluctuation and forms the interdigitation structure, but the mechanism of the pattern formation remains to be elucidated. In...
10.
Haas A, Zihni C, Krug S, Maraspini R, Otani T, Furuse M, et al.
Cells
. 2022 Dec;
11(23).
PMID: 36497035
Formation and maintenance of tissue barriers require the coordination of cell mechanics and cell-cell junction assembly. Here, we combined methods to modulate ECM stiffness and to measure mechanical forces on...