Linc00261 Inhibited High-Grade Serous Ovarian Cancer Progression Through MiR-552-ATG10-EMT Axis

Overview

Journal Comput Math Methods Med

Publisher Hindawi

Specialty Medical Informatics

Date 2022 Apr 25

PMID 35465017

Authors

Lin Wang

Hongcai Wang

Jiuwei Chen

Affiliations

Soon will be listed here.

Abstract

In recent years, long non-coding RNAs (lncRNAs) play an important role in a multitude of pathways across species; however, their functions are still unknown. In this study, we demonstrate that Linc00261 is downregulation in high-grade serous ovarian cancer (HGSOC) and can inhibit cell proliferation and migration of high-grade serous ovarian cancer cells. We further validate the targeting interactions among Linc00261, miR-552, and ATG10. Interestingly, they all play important roles for regulating epithelial-mesenchymal transition (EMT) progression. Collectively, these findings suggest that Linc00261, a mediator of EMT progression, can target oncogenic miR-552, elevating ATG10 expression, to prevent high-grade serous ovarian cancer tumorigenesis and may serve as a potential novel therapeutic target.

Citing Articles

The Role of EMT-Related lncRNAs in Ovarian Cancer.

Lampropoulou D, Papadimitriou M, Papadimitriou C, Filippou D, Kourlaba G, Aravantinos G Int J Mol Sci. 2023; 24(12).

PMID: 37373222 PMC: 10298523. DOI: 10.3390/ijms241210079.

ATG10 overexpression is related to the dismal prognosis and promotes the growth and migration of hepatocellular carcinoma cells via cyclin B1/CDK1 and CDK2.

Li F, Li K, Li D, Zhang W, Yang K, Ke D Am J Cancer Res. 2023; 13(4):1188-1208.

PMID: 37168332 PMC: 10164811.

References

Shi J, Ma H, Wang H, Zhu W, Jiang S, Dou R . Overexpression of LINC00261 inhibits non-small cell lung cancer cells progression by interacting with miR-522-3p and suppressing Wnt signaling. J Cell Biochem. 2019; 120(10):18378-18387. DOI: 10.1002/jcb.29149. View

Davalos V, Esteller M . Disruption of Long Noncoding RNAs Targets Cancer Hallmark Pathways in Lung Tumorigenesis. Cancer Res. 2019; 79(12):3028-3030. DOI: 10.1158/0008-5472.CAN-19-0910. View

Cao J, Yan X, Liu T, Han X, Yu J, Liu S . MicroRNA-552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β-catenin signaling pathway in colorectal cancer. Oncol Lett. 2017; 14(3):3795-3802. PMC: 5588050. DOI: 10.3892/ol.2017.6600. View

Zhao P, Ma Y, Zhao Y, Liu D, Dai Z, Yan C . MicroRNA-552 deficiency mediates 5-fluorouracil resistance by targeting SMAD2 signaling in DNA-mismatch-repair-deficient colorectal cancer. Cancer Chemother Pharmacol. 2019; 84(2):427-439. DOI: 10.1007/s00280-019-03866-7. View

Zhang B, Li C, Sun Z . Long non-coding RNA LINC00346, LINC00578, LINC00673, LINC00671, LINC00261, and SNHG9 are novel prognostic markers for pancreatic cancer. Am J Transl Res. 2018; 10(8):2648-2658. PMC: 6129514. View

Buttarelli M, De Donato M, Raspaglio G, Babini G, Ciucci A, Martinelli E . Clinical Value of lncRNA MEG3 in High-Grade Serous Ovarian Cancer. Cancers (Basel). 2020; 12(4). PMC: 7226118. DOI: 10.3390/cancers12040966. View

Wang X, Hu X, Song W, Xu H, Xiao Z, Huang R . Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation. Cell Res. 2021; 31(6):664-683. PMC: 8169757. DOI: 10.1038/s41422-020-00458-6. View

Zhang H, Li W, Han Y . LINC00261 suppresses cell proliferation, invasion and Notch signaling pathway in hepatocellular carcinoma. Cancer Biomark. 2017; 21(3):575-582. DOI: 10.3233/CBM-170471. View

Horita K, Kurosaki H, Nakatake M, Ito M, Kono H, Nakamura T . Long noncoding RNA UCA1 enhances sensitivity to oncolytic vaccinia virus by sponging miR-18a/miR-182 and modulating the Cdc42/filopodia axis in colorectal cancer. Biochem Biophys Res Commun. 2019; 516(3):831-838. DOI: 10.1016/j.bbrc.2019.06.125. View

10.

Jo K, Santos-Buitrago B, Kim M, Rhee S, Talcott C, Kim S . Logic-based analysis of gene expression data predicts association between TNF, TGFB1 and EGF pathways in basal-like breast cancer. Methods. 2020; 179:89-100. DOI: 10.1016/j.ymeth.2020.05.008. View

11.

Wang J, Zhang X, Chen W, Hu X, Li J, Liu C . Regulatory roles of long noncoding RNAs implicated in cancer hallmarks. Int J Cancer. 2019; 146(4):906-916. DOI: 10.1002/ijc.32277. View

12.

Song Y, Sun J, Zhao J, Yang Y, Shi J, Wu Z . Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion. Nat Commun. 2017; 8(1):289. PMC: 5561086. DOI: 10.1038/s41467-017-00304-1. View

13.

Lu J, Getz G, Miska E, Alvarez-Saavedra E, Lamb J, Peck D . MicroRNA expression profiles classify human cancers. Nature. 2005; 435(7043):834-8. DOI: 10.1038/nature03702. View

14.

Gao J, Yin X, Yu X, Dai C, Zhou F . Long noncoding LINC01551 promotes hepatocellular carcinoma cell proliferation, migration, and invasion by acting as a competing endogenous RNA of microRNA-122-5p to regulate ADAM10 expression. J Cell Biochem. 2019; 120(10):16393-16407. DOI: 10.1002/jcb.28549. View

15.

Manavalan B, Basith S, Shin T, Wei L, Lee G . Meta-4mCpred: A Sequence-Based Meta-Predictor for Accurate DNA 4mC Site Prediction Using Effective Feature Representation. Mol Ther Nucleic Acids. 2019; 16:733-744. PMC: 6540332. DOI: 10.1016/j.omtn.2019.04.019. View

16.

Wei L, Zhou C, Chen H, Song J, Su R . ACPred-FL: a sequence-based predictor using effective feature representation to improve the prediction of anti-cancer peptides. Bioinformatics. 2018; 34(23):4007-4016. PMC: 6247924. DOI: 10.1093/bioinformatics/bty451. View

17.

Dhamija S, Becker A, Sharma Y, Myacheva K, Seiler J, Diederichs S . and the Adjacent Gene Are Epithelial Markers and Are Suppressed during Lung Cancer Tumorigenesis and Progression. Noncoding RNA. 2019; 5(1). PMC: 6468413. DOI: 10.3390/ncrna5010002. View

18.

Qu W, Wen X, Su K, Gou W . MiR-552 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells by inhibiting AJAP1 expression. J Cell Mol Med. 2019; 23(2):1541-1552. PMC: 6349347. DOI: 10.1111/jcmm.14062. View

19.

Fang Q, Sang L, Du S . Long noncoding RNA LINC00261 regulates endometrial carcinoma progression by modulating miRNA/FOXO1 expression. Cell Biochem Funct. 2018; 36(6):323-330. DOI: 10.1002/cbf.3352. View

20.

Clark M, Mercer T, Bussotti G, Leonardi T, Haynes K, Crawford J . Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing. Nat Methods. 2015; 12(4):339-42. DOI: 10.1038/nmeth.3321. View