Non-coding RNAs Participate in the Regulatory Network of CLDN4 Via CeRNA Mediated MiRNA Evasion

Overview

Journal Nat Commun

Specialty Biology

Date 2017 Aug 19

PMID 28819095

Citations 154

Authors

Yong-Xi Song

Jing-Xu Sun

Jun-Hua Zhao

Yu-Chong Yang

Jin-Xin Shi

Zhong-Hua Wu

Xiao-Wan Chen

Peng Gao

Zhi-Feng Miao

Zhen-Ning Wang

Affiliations

Soon will be listed here.

Abstract

Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into "networks" based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p. In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competing endogenous RNAs to affect the function of Claudin-4. Our results suggest that non-coding RNAs play important roles in the regulatory network of Claudin-4. As such, non-coding RNAs should be considered as potential biomarkers and therapeutic targets against gastric cancer.Non-coding RNAs can modify the expression of proteins in cancer networks. Here the authors reveal a regulatory network in gastric cancer whereby claudin-4 expression is reduced by specific miRNAs, which are in turn bound by specific lncRNAs acting as competing endogenous RNAs (ceRNAs), resulting in increased claudin-4 expression.

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