A Formal [3 + 3] Cycloaddition of Allenyl Imide and Activated Ketones for the Synthesis of Tetrasubstituted 2-pyrones

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 Apr 15

PMID 35423364

Authors

Yu-Hao Wang

De-Hua Zhang

Ze-Hun Cao

Wang-Lai Li

Yi-Yong Huang

Affiliations

Soon will be listed here.

Abstract

CsOH·HO-catalyzed formal [3 + 3] cycloadditions of allenyl imide with β-ketoesters, 1,3-diketones or β-ketonitriles for the synthesis of tetrasubstituted 2-pyrone derivatives have been demonstrated. The allenyl imide was utilized as a C3-synthon, and a ketenyl intermediate was proposed the process of 1,4-addition of carbon anion to allene followed by elimination of the 2-oxazolidinyl group.

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